Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents

Susannah H. Bloch, Mingxi Wan, Paul A. Dayton, Katherine W. Ferrara

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

The behavior of a lipid and polymer-shelled ultrasound microbubble contrast agent was studied using high-speed cameras capable of visualizing individual contrast microbubble responses to acoustic interrogation in real time. A high speed camera interfaced to a custom microscope was used to capture still and streak images of individual microbubbles. The lipid-shelled agent expanded after two-cycle pulse and both the shell and its contents fragment as the pressure approaches to 1 MPa. The polymer-shelled agent remained intact at pressures up to 1.5 MPa and exhibited a different destruction mechanism.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalApplied Physics Letters
Volume84
Issue number4
DOIs
StatePublished - Jan 26 2004

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lipids
high speed cameras
polymers
interrogation
destruction
microscopes
fragments
cycles
acoustics
pulses

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. / Bloch, Susannah H.; Wan, Mingxi; Dayton, Paul A.; Ferrara, Katherine W.

In: Applied Physics Letters, Vol. 84, No. 4, 26.01.2004, p. 631-633.

Research output: Contribution to journalArticle

Bloch, Susannah H. ; Wan, Mingxi ; Dayton, Paul A. ; Ferrara, Katherine W. / Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. In: Applied Physics Letters. 2004 ; Vol. 84, No. 4. pp. 631-633.
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