Abstract
The behavior of a lipid and polymer-shelled ultrasound microbubble contrast agent was studied using high-speed cameras capable of visualizing individual contrast microbubble responses to acoustic interrogation in real time. A high speed camera interfaced to a custom microscope was used to capture still and streak images of individual microbubbles. The lipid-shelled agent expanded after two-cycle pulse and both the shell and its contents fragment as the pressure approaches to 1 MPa. The polymer-shelled agent remained intact at pressures up to 1.5 MPa and exhibited a different destruction mechanism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 631-633 |
| Number of pages | 3 |
| Journal | Applied Physics Letters |
| Volume | 84 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 26 2004 |
Fingerprint
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)
Cite this
Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. / Bloch, Susannah H.; Wan, Mingxi; Dayton, Paul A.; Ferrara, Katherine W.
In: Applied Physics Letters, Vol. 84, No. 4, 26.01.2004, p. 631-633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents
AU - Bloch, Susannah H.
AU - Wan, Mingxi
AU - Dayton, Paul A.
AU - Ferrara, Katherine W.
PY - 2004/1/26
Y1 - 2004/1/26
N2 - The behavior of a lipid and polymer-shelled ultrasound microbubble contrast agent was studied using high-speed cameras capable of visualizing individual contrast microbubble responses to acoustic interrogation in real time. A high speed camera interfaced to a custom microscope was used to capture still and streak images of individual microbubbles. The lipid-shelled agent expanded after two-cycle pulse and both the shell and its contents fragment as the pressure approaches to 1 MPa. The polymer-shelled agent remained intact at pressures up to 1.5 MPa and exhibited a different destruction mechanism.
AB - The behavior of a lipid and polymer-shelled ultrasound microbubble contrast agent was studied using high-speed cameras capable of visualizing individual contrast microbubble responses to acoustic interrogation in real time. A high speed camera interfaced to a custom microscope was used to capture still and streak images of individual microbubbles. The lipid-shelled agent expanded after two-cycle pulse and both the shell and its contents fragment as the pressure approaches to 1 MPa. The polymer-shelled agent remained intact at pressures up to 1.5 MPa and exhibited a different destruction mechanism.
UR - http://www.scopus.com/inward/record.url?scp=1242329827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1242329827&partnerID=8YFLogxK
U2 - 10.1063/1.1643544
DO - 10.1063/1.1643544
M3 - Article
AN - SCOPUS:1242329827
VL - 84
SP - 631
EP - 633
JO - Applied Physics Letters
JF - Applied Physics Letters
SN - 0003-6951
IS - 4
ER -