Optical observation of contrast agent destruction

James E. Chomas; Paul A. Dayton; Donovan May; John Allen; Alexander Klibanov; Katherine Ferrara

Optical observation of contrast agent destruction

James E. Chomas, Paul A. Dayton, Donovan May, John Allen, Alexander Klibanov, Katherine Ferrara

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of -700 m/s and peak acceleration of 1.2 × 10¹² m/s² is observed for insonation with a peak pressure of -1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh-Plesset model predict a peak negative wall velocity of -680 m/s and peak acceleration of 2 × 10¹²m/s².

Original language	English (US)
Pages (from-to)	1056-1058
Number of pages	3
Journal	Applied Physics Letters
Volume	77
Issue number	7
State	Published - Aug 14 2000

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

Cite this

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title = "Optical observation of contrast agent destruction",

abstract = "Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of -700 m/s and peak acceleration of 1.2 × 1012 m/s2 is observed for insonation with a peak pressure of -1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh-Plesset model predict a peak negative wall velocity of -680 m/s and peak acceleration of 2 × 1012m/s2.",

author = "Chomas, {James E.} and Dayton, {Paul A.} and Donovan May and John Allen and Alexander Klibanov and Katherine Ferrara",

year = "2000",

month = aug,

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language = "English (US)",

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pages = "1056--1058",

journal = "Applied Physics Letters",

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T1 - Optical observation of contrast agent destruction

AU - Chomas, James E.

AU - Dayton, Paul A.

AU - May, Donovan

AU - Allen, John

AU - Klibanov, Alexander

AU - Ferrara, Katherine

PY - 2000/8/14

Y1 - 2000/8/14

N2 - Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of -700 m/s and peak acceleration of 1.2 × 1012 m/s2 is observed for insonation with a peak pressure of -1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh-Plesset model predict a peak negative wall velocity of -680 m/s and peak acceleration of 2 × 1012m/s2.

AB - Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of -700 m/s and peak acceleration of 1.2 × 1012 m/s2 is observed for insonation with a peak pressure of -1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh-Plesset model predict a peak negative wall velocity of -680 m/s and peak acceleration of 2 × 1012m/s2.

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M3 - Article

AN - SCOPUS:0000346327

VL - 77

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JO - Applied Physics Letters

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Optical observation of contrast agent destruction

Abstract

ASJC Scopus subject areas

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