Optical imaging of Cerenkov light generation from positron-emitting radiotracers

R. Robertson, M. S. Germanos, C. Li, Gregory Mitchell, Simon R Cherry, M. D. Silva

Research output: Contribution to journalArticle

288 Scopus citations

Abstract

Radiotracers labeled with high-energy positron emitters, such as those commonly used for positron emission tomography studies, emit visible light immediately following decay in a medium. This phenomenon, not previously described for these imaging tracers, is consistent with Cerenkov radiation and has several potential applications, especially for in vivo molecular imaging studies. Herein we detail a new molecular imaging tool, Cerenkov Luminescence Imaging, the experiments conducted that support our interpretation of the source of the signal, and proof-of-concept in vivo studies that set the foundation for future application of this new method.

Original languageEnglish (US)
JournalPhysics in Medicine and Biology
Volume54
Issue number16
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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