Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers

Tsung Han Yang, Chanel K. Yee, Meri L. Amweg, Seema Singh, Eric L. Kendall, Andrew M. Dattelbaum, Andrew P. Shreve, C. Jeffrey Brinker, Atui N. Parikh

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The integration of ion-channel transport functions with responses derived from nanostructured and nanoporous silica mesophase materials is demonstrated. Patterned thin-film mesophases consisting of alternating hydrophilic nanoporous regions and hydrophobic nanostructured regions allow for spatially localized proton transport via selective dimerization of gramicidin in lipid bilayers formed on the hydrophilic regions. The adjoining hydrophobic mesostructure doped with a pH sensitive dye reports the transport. The ease of integrating functional membranes and reporters through the use of patterned mesophases should enable high throughput studies of membrane transport.

Original languageEnglish (US)
Pages (from-to)2446-2451
Number of pages6
JournalNano Letters
Volume7
Issue number8
DOIs
StatePublished - Aug 2007

Fingerprint

Phospholipids
Ion Channels
Protons
membranes
Membranes
Gramicidin
Lipid bilayers
protons
Dimerization
Ions
dimerization
Silicon Dioxide
lipids
Coloring Agents
Dyes
dyes
Silica
Throughput
silicon dioxide
Thin films

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Yang, T. H., Yee, C. K., Amweg, M. L., Singh, S., Kendall, E. L., Dattelbaum, A. M., ... Parikh, A. N. (2007). Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers. Nano Letters, 7(8), 2446-2451. https://doi.org/10.1021/nl071184j

Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers. / Yang, Tsung Han; Yee, Chanel K.; Amweg, Meri L.; Singh, Seema; Kendall, Eric L.; Dattelbaum, Andrew M.; Shreve, Andrew P.; Brinker, C. Jeffrey; Parikh, Atui N.

In: Nano Letters, Vol. 7, No. 8, 08.2007, p. 2446-2451.

Research output: Contribution to journalArticle

Yang, TH, Yee, CK, Amweg, ML, Singh, S, Kendall, EL, Dattelbaum, AM, Shreve, AP, Brinker, CJ & Parikh, AN 2007, 'Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers', Nano Letters, vol. 7, no. 8, pp. 2446-2451. https://doi.org/10.1021/nl071184j
Yang TH, Yee CK, Amweg ML, Singh S, Kendall EL, Dattelbaum AM et al. Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers. Nano Letters. 2007 Aug;7(8):2446-2451. https://doi.org/10.1021/nl071184j
Yang, Tsung Han ; Yee, Chanel K. ; Amweg, Meri L. ; Singh, Seema ; Kendall, Eric L. ; Dattelbaum, Andrew M. ; Shreve, Andrew P. ; Brinker, C. Jeffrey ; Parikh, Atui N. / Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers. In: Nano Letters. 2007 ; Vol. 7, No. 8. pp. 2446-2451.
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