Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers

Tsung Han Yang, Chanel K. Yee, Meri L. Amweg, Seema Singh, Eric L. Kendall, Andrew M. Dattelbaum, Andrew P. Shreve, C. Jeffrey Brinker, Atui N. Parikh

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The integration of ion-channel transport functions with responses derived from nanostructured and nanoporous silica mesophase materials is demonstrated. Patterned thin-film mesophases consisting of alternating hydrophilic nanoporous regions and hydrophobic nanostructured regions allow for spatially localized proton transport via selective dimerization of gramicidin in lipid bilayers formed on the hydrophilic regions. The adjoining hydrophobic mesostructure doped with a pH sensitive dye reports the transport. The ease of integrating functional membranes and reporters through the use of patterned mesophases should enable high throughput studies of membrane transport.

Original languageEnglish (US)
Pages (from-to)2446-2451
Number of pages6
JournalNano Letters
Issue number8
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)


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