Optical coherence tractography using intrinsic contrast

Craig J. Goergen, Harsha Radhakrishnan, Sava Sakadžix́, Emiri T. Mandeville, Eng H. Lo, David E. Sosnovik, Vivek Srinivasan

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31 Scopus citations

Abstract

Organs such as the heart and brain possess intricate fiber structures that are best characterized with threedimensional imaging. For instance, diffusion-based, magnetic resonance tractography (MRT) enables studies of connectivity and remodeling during development and disease macroscopically on the millimeter scale. Here we present complementary, high-resolution microscopic optical coherence imaging and analysis methods that, when used in conjunction with clearing techniques, can characterize fiber architecture in intact organs at tissue depths exceeding 1 mm. We anticipate that these techniques can be used to study fiber architecture in situ at microscopic scales not currently accessible to diffusion magentic resonance (MR), and thus, to validate and complement macroscopic structural imaging techniques. Moreover, as these techniques use intrinsic signals and do not require tissue slicing and staining, they can be used for high-throughput, nondestructive evaluation of fiber architecture across large tissue volumes.

Original languageEnglish (US)
Pages (from-to)3882-3884
Number of pages3
JournalOptics Letters
Volume37
Issue number18
DOIs
StatePublished - Sep 15 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Goergen, C. J., Radhakrishnan, H., Sakadžix́, S., Mandeville, E. T., Lo, E. H., Sosnovik, D. E., & Srinivasan, V. (2012). Optical coherence tractography using intrinsic contrast. Optics Letters, 37(18), 3882-3884. https://doi.org/10.1364/OL.37.003882