Optical Coherence Tomography Imaging of Skin Scarring and Fibrosis

A. Mamalis, D. Ho, Jared Jagdeo

Research output: Chapter in Book/Report/Conference proceedingChapter


Optical coherence tomography (OCT) is a real-time imaging device that is transforming clinical diagnosis in dermatology. OCT is an imaging modality that uses light or laser to produce an image of the skin that approximates the histological architecture. These two-dimensional OCT images can provide a qualitative and quantitative assessment of collagen levels within the skin. This collagen assessment allows dermatologists to use OCT as an imaging biomarker to noninvasively diagnose and evaluate diseases characterized by skin fibrosis in lieu of invasive skin biopsies. Despite its current limitations, OCT imaging for the assessment of skin fibrosis is still in its formative stages and is poised to make tremendous strides that parallel the development and refinement of ultrasound over the past 30. years. Using OCT collagen assessment as a noninvasive imaging biomarker for skin fibrosis will not only improve clinical dermatology but also facilitate research that may lead to new insights into the physiology, pathology, and management of skin fibrosis.

Original languageEnglish (US)
Title of host publicationImaging in Dermatology
PublisherElsevier Inc.
Number of pages7
ISBN (Print)9780128028384
StatePublished - Aug 19 2016


  • Fibrosis
  • OCT
  • Optical coherence tomography
  • Scar
  • Skin imaging

ASJC Scopus subject areas

  • Medicine(all)


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