Optical coherence tomography for the quantitative study of cerebrovascular physiology

Vivek Srinivasan, Dmitriy N. Atochin, Harsha Radhakrishnan, James Y. Jiang, Svetlana Ruvinskaya, Weicheng Wu, Scott Barry, Alex E. Cable, Cenk Ayata, Paul L. Huang, David A. Boas

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

Original languageEnglish (US)
Pages (from-to)1339-1345
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

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Keywords

  • hydrogen clearance
  • optical coherence tomography
  • optical imaging
  • vascular biology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Srinivasan, V., Atochin, D. N., Radhakrishnan, H., Jiang, J. Y., Ruvinskaya, S., Wu, W., Barry, S., Cable, A. E., Ayata, C., Huang, P. L., & Boas, D. A. (2011). Optical coherence tomography for the quantitative study of cerebrovascular physiology. Journal of Cerebral Blood Flow and Metabolism, 31(6), 1339-1345. https://doi.org/10.1038/jcbfm.2011.19