Optical coherence tomography and Raman spectroscopy of the retina

Julia W. Evans, Robert Zawadzki, Rui Liu, James W Chan, Stephen M. Lane, John S Werner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combining these imaging modalities. We present an ex vivo OCT microscope combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. The combined instrument will be used to investigate remaining technical challenges to combine these imaging modalities, such as the laser power levels needed to achieve a Raman signal above the noise level without damaging the sample.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume7171
DOIs
StatePublished - 2009
EventMultimodal Biomedical Imaging IV - San Jose, CA, United States
Duration: Jan 24 2009Jan 26 2009

Other

OtherMultimodal Biomedical Imaging IV
CountryUnited States
CitySan Jose, CA
Period1/24/091/26/09

Keywords

  • Optical coherence tomography
  • Raman spectroscopy
  • Retinal imaging

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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