Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

Vivek Srinivasan, Harsha Radhakrishnan, James Y. Jiang, Scott Barry, Alex E. Cable

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
PublisherSPIE
Volume8213
ISBN (Print)9780819488565
DOIs
StatePublished - Jan 1 2012
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Keywords

  • Angiography
  • Hemodynamics
  • Image processing
  • Myelin
  • Neuron
  • Optical Coherence Microscopy
  • Optical Coherence Tomography
  • Scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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