Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

Vivek Srinivasan; Harsha Radhakrishnan; James Y. Jiang; Scott Barry; Alex E. Cable

doi:10.1117/12.911587

Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

Vivek Srinivasan, Harsha Radhakrishnan, James Y. Jiang, Scott Barry, Alex E. Cable

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.

Original language	English (US)
Title of host publication	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Publisher	SPIE
Volume	8213
ISBN (Print)	9780819488565
DOIs	https://doi.org/10.1117/12.911587
State	Published - Jan 1 2012
Externally published	Yes
Event	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States Duration: Jan 23 2012 → Jan 25 2012

Other

Other	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Country/Territory	United States
City	San Francisco, CA
Period	1/23/12 → 1/25/12

Keywords

Angiography
Hemodynamics
Image processing
Myelin
Neuron
Optical Coherence Microscopy
Optical Coherence Tomography
Scattering

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1117/12.911587

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Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast. / Srinivasan, Vivek; Radhakrishnan, Harsha; Jiang, James Y.; Barry, Scott; Cable, Alex E.

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI. Vol. 8213 SPIE, 2012. 82131Y.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Srinivasan, V, Radhakrishnan, H, Jiang, JY, Barry, S & Cable, AE 2012, Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI. vol. 8213, 82131Y, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, San Francisco, CA, United States, 1/23/12. https://doi.org/10.1117/12.911587

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abstract = "We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.",

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AU - Radhakrishnan, Harsha

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AU - Barry, Scott

AU - Cable, Alex E.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.

AB - We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.

KW - Angiography

KW - Hemodynamics

KW - Image processing

KW - Myelin

KW - Neuron

KW - Optical Coherence Microscopy

KW - Optical Coherence Tomography

KW - Scattering

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M3 - Conference contribution

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SN - 9780819488565

VL - 8213

BT - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

PB - SPIE

T2 - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

Y2 - 23 January 2012 through 25 January 2012

ER -

Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

Abstract

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Keywords

ASJC Scopus subject areas

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