Abstract
We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.
| Original language | English (US) |
|---|---|
| Title of host publication | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI |
| Publisher | SPIE |
| Volume | 8213 |
| ISBN (Print) | 9780819488565 |
| DOIs | |
| State | Published - Jan 1 2012 |
| Externally published | Yes |
| Event | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States Duration: Jan 23 2012 → Jan 25 2012 |
Other
| Other | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 1/23/12 → 1/25/12 |
Keywords
- Angiography
- Hemodynamics
- Image processing
- Myelin
- Neuron
- Optical Coherence Microscopy
- Optical Coherence Tomography
- Scattering
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging
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Cite this
Srinivasan, V., Radhakrishnan, H., Jiang, J. Y., Barry, S., & Cable, A. E. (2012). Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI (Vol. 8213). [82131Y] SPIE. https://doi.org/10.1117/12.911587