Opportunistic bacterial infections in breeding colonies of the NSG Mouse Strain

O. Foreman, A. M. Kavirayani, S. M. Griffey, R. Reader, L. D. Shultz

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Spontaneous morbidity primarily affecting female breeders in 3 independent breeding colonies of NSG (NOD.Cg-Prkdcscid I12rgtm1Wjl/SzJ) mice prompted an investigation to uncover the cause of disease. Necropsies were performed on 264 (157 female and 107 male) spontaneously sick, experimentally unmanipulated NSG mice. In sum, 42 mice (15.9%) had acute or chronic renal inflammatory lesions, of which 12 had concurrent histologic evidence of an ascending urinary tract infection. From 94 kidneys cultured for bacterial organisms, 23 (24.5%) grew Enterococcus sp and 19 (20.2%) grew Klebsiella oxytoca. Female mice were twice more likely than males to present with nephritis. These findings indicate that bacterial nephritis is a major contributor to morbidity in the NSG strain.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalVeterinary Pathology
Volume48
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • immunodeficiency
  • interleukin-2
  • mouse
  • nephritis
  • NSG
  • urinary tract infection

ASJC Scopus subject areas

  • veterinary(all)

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