Opioidergic and dopaminergic gene expression in the caudate-putamen and accumbens of the mutant mouse, tottering (tg/tg)

Andrea De Bartolomeis, Vuk Koprivica, David Pickar, Jacqueline Crawley, Louise C. Abbott

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Expression of preproenkephalin, dynorphin and D2 dopamine receptor mRNAs was examined in selected regions of the forebrain of homozygous and heterozygous tottering mice, using in situ hybridization histochemistry. Homozygous tottering mice carry an autosomal recessive mutation causing them to exhibit petit mal-like epilepsy. Preproenkephalin mRNA levels were significantly higher in the lateral caudate and the core of the nucleus accumbens of homozygous tottering mice compared to wild-type controls. No differences were observed in the expression of dynorphin and D2 receptor mRNA distribution in brain regions examined in the mutant mice as compared to wild-type controls.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalMolecular Brain Research
Volume46
Issue number1-2
DOIs
StatePublished - Jun 1997
Externally publishedYes

Keywords

  • D dopamine receptor
  • Dynorphin
  • Enkephalin
  • Epilepsy
  • Hybridization histochemistry, in situ
  • mRNA
  • Striatum

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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