Opioid-receptor-heteromer-specific trafficking and pharmacology

Richard M. van Rijn, Jennifer Whistler, Maria Waldhoer

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially apparent for the field of opioid receptors. Drugs have been identified that selectively target opioid heteromers of the delta-opioid receptor with the kappa and the mu-opioid receptors that influence nociception and ethanol consumption, respectively. In addition, in several cases, the specific physiological response produced by the heteromer may be directly attributed to a difference in receptor trafficking properties of the heteromers compared with their homomeric counterparts. This review attempts to highlight some of the latest developments with regard to opioid receptor heteromer trafficking and pharmacology.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Fingerprint

Opioid Receptors
Pharmacology
Artificial Cells
kappa Opioid Receptor
delta Opioid Receptor
Nociception
mu Opioid Receptor
G-Protein-Coupled Receptors
Opioid Analgesics
Ethanol
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Opioid-receptor-heteromer-specific trafficking and pharmacology. / van Rijn, Richard M.; Whistler, Jennifer; Waldhoer, Maria.

In: Current Opinion in Pharmacology, Vol. 10, No. 1, 01.02.2010, p. 73-79.

Research output: Contribution to journalReview article

van Rijn, Richard M. ; Whistler, Jennifer ; Waldhoer, Maria. / Opioid-receptor-heteromer-specific trafficking and pharmacology. In: Current Opinion in Pharmacology. 2010 ; Vol. 10, No. 1. pp. 73-79.
@article{e058366d2b1b406dbfcc864530ec336f,
title = "Opioid-receptor-heteromer-specific trafficking and pharmacology",
abstract = "Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially apparent for the field of opioid receptors. Drugs have been identified that selectively target opioid heteromers of the delta-opioid receptor with the kappa and the mu-opioid receptors that influence nociception and ethanol consumption, respectively. In addition, in several cases, the specific physiological response produced by the heteromer may be directly attributed to a difference in receptor trafficking properties of the heteromers compared with their homomeric counterparts. This review attempts to highlight some of the latest developments with regard to opioid receptor heteromer trafficking and pharmacology.",
author = "{van Rijn}, {Richard M.} and Jennifer Whistler and Maria Waldhoer",
year = "2010",
month = "2",
day = "1",
doi = "10.1016/j.coph.2009.09.007",
language = "English (US)",
volume = "10",
pages = "73--79",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Opioid-receptor-heteromer-specific trafficking and pharmacology

AU - van Rijn, Richard M.

AU - Whistler, Jennifer

AU - Waldhoer, Maria

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially apparent for the field of opioid receptors. Drugs have been identified that selectively target opioid heteromers of the delta-opioid receptor with the kappa and the mu-opioid receptors that influence nociception and ethanol consumption, respectively. In addition, in several cases, the specific physiological response produced by the heteromer may be directly attributed to a difference in receptor trafficking properties of the heteromers compared with their homomeric counterparts. This review attempts to highlight some of the latest developments with regard to opioid receptor heteromer trafficking and pharmacology.

AB - Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially apparent for the field of opioid receptors. Drugs have been identified that selectively target opioid heteromers of the delta-opioid receptor with the kappa and the mu-opioid receptors that influence nociception and ethanol consumption, respectively. In addition, in several cases, the specific physiological response produced by the heteromer may be directly attributed to a difference in receptor trafficking properties of the heteromers compared with their homomeric counterparts. This review attempts to highlight some of the latest developments with regard to opioid receptor heteromer trafficking and pharmacology.

UR - http://www.scopus.com/inward/record.url?scp=72449123327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72449123327&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2009.09.007

DO - 10.1016/j.coph.2009.09.007

M3 - Review article

C2 - 19846340

AN - SCOPUS:72449123327

VL - 10

SP - 73

EP - 79

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

IS - 1

ER -