Opioid-receptor-heteromer-specific trafficking and pharmacology

Richard M. van Rijn, Jennifer Whistler, Maria Waldhoer

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially apparent for the field of opioid receptors. Drugs have been identified that selectively target opioid heteromers of the delta-opioid receptor with the kappa and the mu-opioid receptors that influence nociception and ethanol consumption, respectively. In addition, in several cases, the specific physiological response produced by the heteromer may be directly attributed to a difference in receptor trafficking properties of the heteromers compared with their homomeric counterparts. This review attempts to highlight some of the latest developments with regard to opioid receptor heteromer trafficking and pharmacology.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalCurrent Opinion in Pharmacology
Issue number1
StatePublished - Feb 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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