Opiate modification of amygdaloid-kindled seizures in rats

William S. Stone, Cindy E. Eggleton, Robert F Berman

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Male Long-Evans rats were stereotaxically implanted bilaterally with bipolar electrodes in the central amygdala. Rats were then kindled once daily for 1 sec until 3 consecutive Stage V [25] kindled seizures were elicited. On the following day, animals were injected (IP) with either saline, naloxone (10 mg/kg), naltrexone (10 mg/kg) or morphine sulfate (10 mg/kg) and again stimulated parameters the kindling stimulation parameters. Saline injected animals continued to show long bilateral AD's and behaviors (i.e., forelimb clonus, rearing, falling) typical of Stage V kindled animals. In contrast, rats injected with naloxone or naltrexone showed reduced behavioral seizures. Potentiation of post-ictal spiking by morphine in amygdaloid-kindled rats was also observed supporting previous reports [7,21]. In a second experiment, the reduction of kindled seizure severity by naloxone was systematically replicated. It is concluded that opiates can significantly modify amygaloid-kindled seizures, and that brain endorphins may play a role in the development of maintenance of an amygdaloid-kindled seizure focus.

Original languageEnglish (US)
Pages (from-to)751-756
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number5
DOIs
StatePublished - 1982
Externally publishedYes

Keywords

  • Amygdala
  • Kindling
  • Morphine
  • Naloxone
  • Naltrexone

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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