Ophthalmologic disorders and risk factors in children with autism spectrum disorder

Research output: Contribution to journalArticle

Abstract

Purpose: To report the results of our review of all children with autism spectrum disorder (ASD) who underwent complete pediatric ophthalmologic examination at our institution over a 10-year period. Methods: The medical records of all children (0-17 years of age) with a diagnosis of ASD seen at University of California, Davis, over a 10-year period were reviewed retrospectively. Demographic data, birth history, genetic testing results, neuropsychiatric comorbidities, and ophthalmologic findings were extracted from the record. Multiple logistic regression was used to identify risk factors for ophthalmologic disorders. Results: A total of 2,555 children with ASD were seen at the university over the study period, of whom 380 (15%) were evaluated in the ophthalmology clinic. Eye examination revealed an ophthalmic diagnosis in 71% of children, of which the most common were significant refractive error (42%), strabismus (32%), and amblyopia (19%). Optic neuropathy occurred in 14 children (4%). Cerebral palsy was a significant risk factor for refractive error (OR = 3.22; P = 0.016), strabismus (OR = 3.59; P = 0.012), amblyopia (OR = 3.49; P = 0.0097), and optic neuropathy (OR = 14.0; P = 0.0009). Conclusions: Ophthalmic disorders were found in 71% of children with ASD evaluated at our university-based ophthalmology clinic. The rates of significant refractive error, strabismus, amblyopia, and optic neuropathy exceeded those of the general pediatric population. ASD and cerebral palsy may have additive risk for these disorders.

Original languageEnglish (US)
JournalJournal of AAPOS
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Optic Nerve Diseases
Amblyopia
Refractive Errors
Strabismus
Cerebral Palsy
Ophthalmology
Pediatrics
Reproductive History
Genetic Testing
Medical Records
Autism Spectrum Disorder
Comorbidity
Logistic Models
Demography
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

@article{969e09d490734ecbb2685cac6a9f7308,
title = "Ophthalmologic disorders and risk factors in children with autism spectrum disorder",
abstract = "Purpose: To report the results of our review of all children with autism spectrum disorder (ASD) who underwent complete pediatric ophthalmologic examination at our institution over a 10-year period. Methods: The medical records of all children (0-17 years of age) with a diagnosis of ASD seen at University of California, Davis, over a 10-year period were reviewed retrospectively. Demographic data, birth history, genetic testing results, neuropsychiatric comorbidities, and ophthalmologic findings were extracted from the record. Multiple logistic regression was used to identify risk factors for ophthalmologic disorders. Results: A total of 2,555 children with ASD were seen at the university over the study period, of whom 380 (15{\%}) were evaluated in the ophthalmology clinic. Eye examination revealed an ophthalmic diagnosis in 71{\%} of children, of which the most common were significant refractive error (42{\%}), strabismus (32{\%}), and amblyopia (19{\%}). Optic neuropathy occurred in 14 children (4{\%}). Cerebral palsy was a significant risk factor for refractive error (OR = 3.22; P = 0.016), strabismus (OR = 3.59; P = 0.012), amblyopia (OR = 3.49; P = 0.0097), and optic neuropathy (OR = 14.0; P = 0.0009). Conclusions: Ophthalmic disorders were found in 71{\%} of children with ASD evaluated at our university-based ophthalmology clinic. The rates of significant refractive error, strabismus, amblyopia, and optic neuropathy exceeded those of the general pediatric population. ASD and cerebral palsy may have additive risk for these disorders.",
author = "Chang, {Melinda Y.} and Nandini Gandhi and Mary O'Hara",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jaapos.2019.09.008",
language = "English (US)",
journal = "Journal of AAPOS",
issn = "1091-8531",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Ophthalmologic disorders and risk factors in children with autism spectrum disorder

AU - Chang, Melinda Y.

AU - Gandhi, Nandini

AU - O'Hara, Mary

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To report the results of our review of all children with autism spectrum disorder (ASD) who underwent complete pediatric ophthalmologic examination at our institution over a 10-year period. Methods: The medical records of all children (0-17 years of age) with a diagnosis of ASD seen at University of California, Davis, over a 10-year period were reviewed retrospectively. Demographic data, birth history, genetic testing results, neuropsychiatric comorbidities, and ophthalmologic findings were extracted from the record. Multiple logistic regression was used to identify risk factors for ophthalmologic disorders. Results: A total of 2,555 children with ASD were seen at the university over the study period, of whom 380 (15%) were evaluated in the ophthalmology clinic. Eye examination revealed an ophthalmic diagnosis in 71% of children, of which the most common were significant refractive error (42%), strabismus (32%), and amblyopia (19%). Optic neuropathy occurred in 14 children (4%). Cerebral palsy was a significant risk factor for refractive error (OR = 3.22; P = 0.016), strabismus (OR = 3.59; P = 0.012), amblyopia (OR = 3.49; P = 0.0097), and optic neuropathy (OR = 14.0; P = 0.0009). Conclusions: Ophthalmic disorders were found in 71% of children with ASD evaluated at our university-based ophthalmology clinic. The rates of significant refractive error, strabismus, amblyopia, and optic neuropathy exceeded those of the general pediatric population. ASD and cerebral palsy may have additive risk for these disorders.

AB - Purpose: To report the results of our review of all children with autism spectrum disorder (ASD) who underwent complete pediatric ophthalmologic examination at our institution over a 10-year period. Methods: The medical records of all children (0-17 years of age) with a diagnosis of ASD seen at University of California, Davis, over a 10-year period were reviewed retrospectively. Demographic data, birth history, genetic testing results, neuropsychiatric comorbidities, and ophthalmologic findings were extracted from the record. Multiple logistic regression was used to identify risk factors for ophthalmologic disorders. Results: A total of 2,555 children with ASD were seen at the university over the study period, of whom 380 (15%) were evaluated in the ophthalmology clinic. Eye examination revealed an ophthalmic diagnosis in 71% of children, of which the most common were significant refractive error (42%), strabismus (32%), and amblyopia (19%). Optic neuropathy occurred in 14 children (4%). Cerebral palsy was a significant risk factor for refractive error (OR = 3.22; P = 0.016), strabismus (OR = 3.59; P = 0.012), amblyopia (OR = 3.49; P = 0.0097), and optic neuropathy (OR = 14.0; P = 0.0009). Conclusions: Ophthalmic disorders were found in 71% of children with ASD evaluated at our university-based ophthalmology clinic. The rates of significant refractive error, strabismus, amblyopia, and optic neuropathy exceeded those of the general pediatric population. ASD and cerebral palsy may have additive risk for these disorders.

UR - http://www.scopus.com/inward/record.url?scp=85075336809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075336809&partnerID=8YFLogxK

U2 - 10.1016/j.jaapos.2019.09.008

DO - 10.1016/j.jaapos.2019.09.008

M3 - Article

C2 - 31676470

AN - SCOPUS:85075336809

JO - Journal of AAPOS

JF - Journal of AAPOS

SN - 1091-8531

ER -