Open lung biopsy in the critically ill newborn

H. W. Cheu, K. P. Lally, R. Clark, S. Harrell, Donald Null

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Experience with 17 open lung biopsies in critically ill premature neonates was reviewed. Despite their small size, prematurity, and near maximal ventilator requirements, the infants suffered no significant complications. In three cases, an infectious agent was identified. In one case end-stage lung fibrosis associated with persistent (>3 months), severe respiratory failure prompted termination of support. In the remainder of the cases, definitively ruling out infection allowed the confident trial of a course of steroids in an attempt to treat bronchopulmonary dysplasia. Unlike older patients, the definitive diagnosis of no infection in the premature neonate is just as informative as the diagnosis of an infection. Used judiciously, open lung biopsy can be performed in the premature infant with acceptable morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)561-563
Number of pages3
Issue number4
StatePublished - Jan 1 1990
Externally publishedYes


  • Mycoplasma
  • open lung biopsy
  • preterm neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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