Oocyte Quality Control: Causes, Mechanisms, and Consequences

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Oocyte quality and number are key determinants of reproductive life span and success. These variables are shaped in part by the elimination of oocytes that experience problems during the early stages of meiosis. Meiotic prophase-I marks an extended period of genome vulnerability in which epigenetic reprogramming unleashes retroelements and hundreds of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination required for accurate chromosome segregation at the first meiotic division. Expression of LINE-1 retroelements perturbs several aspects of meiotic prophase and is associated with oocyte death during the early stages of meiotic prophase I. Defects in chromosome synapsis and recombination also trigger oocyte loss, but typically at a later stage, as cells transition into quiescence and form primordial follicles. Interrelated pathways that signal defects in DSB repair and chromosome synapsis mediate this late oocyte attrition. Here, I review our current understanding of early and late oocyte attrition based on studies in mouse and describe how these processes appear to be both distinct and overlapping and how they help balance the quality and size of oocyte reserves to maximize fecundity.

Original languageEnglish (US)
Pages (from-to)235-247
Number of pages13
JournalCold Spring Harbor symposia on quantitative biology
Volume82
DOIs
StatePublished - Jan 1 2017

Fingerprint

Chromosomes
Quality Control
Oocytes
Quality control
Retroelements
Defects
Meiotic Prophase I
Chromosome Pairing
Repair
Genetic Recombination
Genes
DNA
Chromosome Breakage
Prophase
Chromosome Segregation
Double-Stranded DNA Breaks
Meiosis
Epigenomics
Fertility
Signal Transduction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Oocyte Quality Control : Causes, Mechanisms, and Consequences. / Hunter, Neil.

In: Cold Spring Harbor symposia on quantitative biology, Vol. 82, 01.01.2017, p. 235-247.

Research output: Contribution to journalArticle

@article{ee806bab8ae54600acaa7c0cff40f506,
title = "Oocyte Quality Control: Causes, Mechanisms, and Consequences",
abstract = "Oocyte quality and number are key determinants of reproductive life span and success. These variables are shaped in part by the elimination of oocytes that experience problems during the early stages of meiosis. Meiotic prophase-I marks an extended period of genome vulnerability in which epigenetic reprogramming unleashes retroelements and hundreds of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination required for accurate chromosome segregation at the first meiotic division. Expression of LINE-1 retroelements perturbs several aspects of meiotic prophase and is associated with oocyte death during the early stages of meiotic prophase I. Defects in chromosome synapsis and recombination also trigger oocyte loss, but typically at a later stage, as cells transition into quiescence and form primordial follicles. Interrelated pathways that signal defects in DSB repair and chromosome synapsis mediate this late oocyte attrition. Here, I review our current understanding of early and late oocyte attrition based on studies in mouse and describe how these processes appear to be both distinct and overlapping and how they help balance the quality and size of oocyte reserves to maximize fecundity.",
author = "Neil Hunter",
year = "2017",
month = "1",
day = "1",
doi = "10.1101/sqb.2017.82.035394",
language = "English (US)",
volume = "82",
pages = "235--247",
journal = "Cold Spring Harbor Symposia on Quantitative Biology",
issn = "0091-7451",
publisher = "Cold Spring Harbor Laboratory Press",

}

TY - JOUR

T1 - Oocyte Quality Control

T2 - Causes, Mechanisms, and Consequences

AU - Hunter, Neil

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Oocyte quality and number are key determinants of reproductive life span and success. These variables are shaped in part by the elimination of oocytes that experience problems during the early stages of meiosis. Meiotic prophase-I marks an extended period of genome vulnerability in which epigenetic reprogramming unleashes retroelements and hundreds of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination required for accurate chromosome segregation at the first meiotic division. Expression of LINE-1 retroelements perturbs several aspects of meiotic prophase and is associated with oocyte death during the early stages of meiotic prophase I. Defects in chromosome synapsis and recombination also trigger oocyte loss, but typically at a later stage, as cells transition into quiescence and form primordial follicles. Interrelated pathways that signal defects in DSB repair and chromosome synapsis mediate this late oocyte attrition. Here, I review our current understanding of early and late oocyte attrition based on studies in mouse and describe how these processes appear to be both distinct and overlapping and how they help balance the quality and size of oocyte reserves to maximize fecundity.

AB - Oocyte quality and number are key determinants of reproductive life span and success. These variables are shaped in part by the elimination of oocytes that experience problems during the early stages of meiosis. Meiotic prophase-I marks an extended period of genome vulnerability in which epigenetic reprogramming unleashes retroelements and hundreds of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination required for accurate chromosome segregation at the first meiotic division. Expression of LINE-1 retroelements perturbs several aspects of meiotic prophase and is associated with oocyte death during the early stages of meiotic prophase I. Defects in chromosome synapsis and recombination also trigger oocyte loss, but typically at a later stage, as cells transition into quiescence and form primordial follicles. Interrelated pathways that signal defects in DSB repair and chromosome synapsis mediate this late oocyte attrition. Here, I review our current understanding of early and late oocyte attrition based on studies in mouse and describe how these processes appear to be both distinct and overlapping and how they help balance the quality and size of oocyte reserves to maximize fecundity.

UR - http://www.scopus.com/inward/record.url?scp=85062436772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062436772&partnerID=8YFLogxK

U2 - 10.1101/sqb.2017.82.035394

DO - 10.1101/sqb.2017.82.035394

M3 - Article

C2 - 29743337

AN - SCOPUS:85062436772

VL - 82

SP - 235

EP - 247

JO - Cold Spring Harbor Symposia on Quantitative Biology

JF - Cold Spring Harbor Symposia on Quantitative Biology

SN - 0091-7451

ER -