Ontogeny of host responses in ovine fetuses infected with bluetongue virus.

F. M. Enright, Bennie Osburn

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Ovine fetuses were inoculated (IM) with bluetongue virus (BTV) between the 50th and the 130th days of a 150-day gestation. At 10 to 15 days after virus was inoculated, the interstitial tissue of the fetal lung was diffusely infiltrated with large mononuclear leukocytes. By 20 days, unitized nodules of macrophages were seen in the interstitial tissue of the lung. The only gross alterations observed in infected fetuses were large lymph nodes and prominent lymphoid nodules within the spleen. Fetuses inoculated on the 80th day developed increased serum concentrations of immunoglobulin G (IgG) within 20 days after inoculation, whereas fetuses inoculated on the 100th gestational day and later developed increased concentrations of IgG by 10 days. Fetuses inoculated on the 80th gestational day also developed serum neutralizing antibodies by 20 days after infection. The BTV was recovered from fetuses which had serum neutalizing antibody. The sequential development of responses to BTV infection during ontogeny in ovine fetuses is discussed.

Original languageEnglish (US)
Pages (from-to)224-229
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume41
Issue number2
StatePublished - Feb 1 1980
Externally publishedYes

Fingerprint

Bluetongue virus
fetus
ontogeny
Sheep
Fetus
sheep
immunoglobulin G
lungs
Immunoglobulin G
Serum
Mononuclear Leukocytes
Lung
mononuclear leukocytes
neutralizing antibodies
infection
Virus Diseases
Neutralizing Antibodies
lymph nodes
spleen
macrophages

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ontogeny of host responses in ovine fetuses infected with bluetongue virus. / Enright, F. M.; Osburn, Bennie.

In: American Journal of Veterinary Research, Vol. 41, No. 2, 01.02.1980, p. 224-229.

Research output: Contribution to journalArticle

Enright, F. M. ; Osburn, Bennie. / Ontogeny of host responses in ovine fetuses infected with bluetongue virus. In: American Journal of Veterinary Research. 1980 ; Vol. 41, No. 2. pp. 224-229.
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