Abstract
There are a number of factors which contribute to the large number of congenital infections which occur in domestic animals. The more important factors include: 1) The agammaglobulinemic fetus because of a lack of transplacental transfer of maternal immunoglobulins, 2) An immature immune and accessory immune system, and 3) Undifferentiated cells in a number of developing organ systems in the fetus. The immune and accessory immune systems and other organ systems develop in a sequential manner. The types of lesions associated with a microbial agent depends upon the status of the target organ, immune response and accessory immune response at the particular moment of the insult. Once immune competence is attained, the fetus clears infection. Immune tolerance occurs with certain pestiviruses which have a predilection for lymphoid cells. Infection must occur before immune competence to these viruses is attained.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-32 |
| Number of pages | 18 |
| Journal | Progress in Clinical and Biological Research |
| Volume | 281 |
| State | Published - Jan 1 1988 |
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ASJC Scopus subject areas
- Medicine(all)
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Ontogeny of host defense systems and congenital infections. / Osburn, Bennie.
In: Progress in Clinical and Biological Research, Vol. 281, 01.01.1988, p. 15-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ontogeny of host defense systems and congenital infections.
AU - Osburn, Bennie
PY - 1988/1/1
Y1 - 1988/1/1
N2 - There are a number of factors which contribute to the large number of congenital infections which occur in domestic animals. The more important factors include: 1) The agammaglobulinemic fetus because of a lack of transplacental transfer of maternal immunoglobulins, 2) An immature immune and accessory immune system, and 3) Undifferentiated cells in a number of developing organ systems in the fetus. The immune and accessory immune systems and other organ systems develop in a sequential manner. The types of lesions associated with a microbial agent depends upon the status of the target organ, immune response and accessory immune response at the particular moment of the insult. Once immune competence is attained, the fetus clears infection. Immune tolerance occurs with certain pestiviruses which have a predilection for lymphoid cells. Infection must occur before immune competence to these viruses is attained.
AB - There are a number of factors which contribute to the large number of congenital infections which occur in domestic animals. The more important factors include: 1) The agammaglobulinemic fetus because of a lack of transplacental transfer of maternal immunoglobulins, 2) An immature immune and accessory immune system, and 3) Undifferentiated cells in a number of developing organ systems in the fetus. The immune and accessory immune systems and other organ systems develop in a sequential manner. The types of lesions associated with a microbial agent depends upon the status of the target organ, immune response and accessory immune response at the particular moment of the insult. Once immune competence is attained, the fetus clears infection. Immune tolerance occurs with certain pestiviruses which have a predilection for lymphoid cells. Infection must occur before immune competence to these viruses is attained.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023731535&partnerID=8YFLogxK
M3 - Article
VL - 281
SP - 15
EP - 32
JO - Progress in Clinical and Biological Research
JF - Progress in Clinical and Biological Research
SN - 0361-7742
ER -