Ontogeny of host defense systems and congenital infections.

Research output: Contribution to journalArticle

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Abstract

There are a number of factors which contribute to the large number of congenital infections which occur in domestic animals. The more important factors include: 1) The agammaglobulinemic fetus because of a lack of transplacental transfer of maternal immunoglobulins, 2) An immature immune and accessory immune system, and 3) Undifferentiated cells in a number of developing organ systems in the fetus. The immune and accessory immune systems and other organ systems develop in a sequential manner. The types of lesions associated with a microbial agent depends upon the status of the target organ, immune response and accessory immune response at the particular moment of the insult. Once immune competence is attained, the fetus clears infection. Immune tolerance occurs with certain pestiviruses which have a predilection for lymphoid cells. Infection must occur before immune competence to these viruses is attained.

Original languageEnglish (US)
Pages (from-to)15-32
Number of pages18
JournalProgress in Clinical and Biological Research
Volume281
StatePublished - Jan 1 1988

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Fetus
Mental Competency
Immune System
Infection
Pestivirus
Immune Tolerance
Domestic Animals
Immunoglobulins
Mothers
Lymphocytes
Viruses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ontogeny of host defense systems and congenital infections. / Osburn, Bennie.

In: Progress in Clinical and Biological Research, Vol. 281, 01.01.1988, p. 15-32.

Research output: Contribution to journalArticle

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