Abstract
We hypothesized that lumbar sympathetic nerve activity (LSNA) increases at the onset of whole-body dynamic exercise in the rat. To test this hypothesis, we recorded LSNA, heart rate (HR), and arterial pressure (AP) at rest and during a graded exercise test in six adult rats. Rats were instrumented with arterial and venous catheters and recording electrodes around the lumbar sympathetic trunk. Following recovery, each rat ran continuously on a hand- driven or motorized treadmill at 6 m·min-1, 12 m·min-1, and 18 m-min- 1 on a 10% grade for approximately 3 min at each workload. Before exercise, mean arterial pressure (MAP), HR, and LSNA averaged 108 ± 4 mm Hg, 385 ± 20 bpm, and 100%, respectively. As hypothesized, all variables increased abruptly and dramatically at the onset of treadmill exercise. For example, MAP (117 ± 5 mm Hg), HR (450 ± 15 bpm), and LSNA (225 ± 19%) all increased significantly within the first 25 s of treadmill running at 6 m·min-1. As the exercise continued, there was a progressive increase in HR; however, MAP plateaued at 6 m·min-1 and LSNA plateaued at 12 m·min-1. Since LSNA increased at the onset of whole-body dynamic exercise in the rat, we suggest that the increase in LSNA at the onset of exercise is mediated by a central (feed forward) mechanism.
Original language | English (US) |
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Pages (from-to) | 677-684 |
Number of pages | 8 |
Journal | Medicine and Science in Sports and Exercise |
Volume | 28 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1996 |
Externally published | Yes |
Keywords
- BAROREFLEX RESETTING
- BLOOD PRESSURE
- HEART RATE
- TREADMILL EXERCISE
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Physical Therapy, Sports Therapy and Rehabilitation
- Orthopedics and Sports Medicine