TY - JOUR
T1 - One-Year stability of frontoparietal cognitive control network connectivity in recent onset schizophrenia
T2 - A task-related 3T fMRI study
AU - Smucny, Jason
AU - Lesh, Tyler A.
AU - Zarubin, Vanessa C.
AU - Niendam, Tara A.
AU - Daniel Ragland, J.
AU - Tully, Laura M.
AU - Carter, Cameron S.
N1 - Funding Information:
This study was supported by National Institutes of Health (MH059883 to Dr. Carter, MH114325 to Dr. Smucny and HD051958 to Dr. Tully). We thank Rylee Brower, Amber Howell, Benjamin Geib, Madison Titone, Taylor Salo, Estera (Neli) Mihov, Erika Steinbauer, Markie Benavidez, and Huan Wang for their assistance with data collection and processing. We also thank the study participants and their families. A portion of these data were presented the 2019 Society of Biological Psychiatry Annual Meeting.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Kraepelinian theory posits that schizophrenia (SZ) is a degenerative disorder that worsens throughout the lifespan. Behavioral studies of cognition have since challenged that viewpoint, particularly in the early phases of illness. Nonetheless, the extent to which cognition remains functionally stable during the early course of illness is unclear, particularly with regard to task-associated connectivity in cognition-related brain networks. In this study, we examined the 1-year stability of the frontoparietal control network during the AX-Continuous Performance Task (AX-CPT) from a new baseline sample of 153 participants scanned at 3T, of which 29 recent onset individuals with SZ and 42 healthy control (HC) participants had follow-up data available for analysis. Among individuals that had both baseline and follow-up data, reduced functional connectivity in SZ was observed between the dorsolateral prefrontal cortex (DLPFC) and superior parietal cortex (SPC) during the high control (B cue) condition. Furthermore, this deficit was stable over time, as no significant time × diagnosis interaction or effects of time were observed and intraclass correlation coefficients were greater than 0.6 in HCs and SZ. Previous 1.5T findings showing stable deficits with no evidence of degeneration in performance or DLPFC activation in an independent SZ sample were replicated. Overall, these results suggest that the neuronal circuitry supporting cognitive control is stably impaired during the early course of illness in SZ across multiple levels of analysis with no evidence of functional decline.
AB - Kraepelinian theory posits that schizophrenia (SZ) is a degenerative disorder that worsens throughout the lifespan. Behavioral studies of cognition have since challenged that viewpoint, particularly in the early phases of illness. Nonetheless, the extent to which cognition remains functionally stable during the early course of illness is unclear, particularly with regard to task-associated connectivity in cognition-related brain networks. In this study, we examined the 1-year stability of the frontoparietal control network during the AX-Continuous Performance Task (AX-CPT) from a new baseline sample of 153 participants scanned at 3T, of which 29 recent onset individuals with SZ and 42 healthy control (HC) participants had follow-up data available for analysis. Among individuals that had both baseline and follow-up data, reduced functional connectivity in SZ was observed between the dorsolateral prefrontal cortex (DLPFC) and superior parietal cortex (SPC) during the high control (B cue) condition. Furthermore, this deficit was stable over time, as no significant time × diagnosis interaction or effects of time were observed and intraclass correlation coefficients were greater than 0.6 in HCs and SZ. Previous 1.5T findings showing stable deficits with no evidence of degeneration in performance or DLPFC activation in an independent SZ sample were replicated. Overall, these results suggest that the neuronal circuitry supporting cognitive control is stably impaired during the early course of illness in SZ across multiple levels of analysis with no evidence of functional decline.
KW - AX-CPT
KW - Dorsolateral prefrontal cortex
KW - Functional connectivity
KW - Intraclass correlation coefficient
KW - Longitudinal
KW - Superior parietal cortex
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U2 - 10.1093/schbul/sbz122
DO - 10.1093/schbul/sbz122
M3 - Article
C2 - 31903495
AN - SCOPUS:85082834978
VL - 46
SP - 1249
EP - 1258
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 5
ER -