One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

Yi Chen; Vireak Thon; Yanhong Li; Hai Yu; Li Ding; Kam Lau; Jingyao Qu; Liana Hie; Xi Chen

doi:10.1039/c1cc14034e

One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

Yi Chen, Vireak Thon, Yanhong Li, Hai Yu, Li Ding, Kam Lau, Jingyao Qu, Liana Hie, Xi Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

Original language	English (US)
Pages (from-to)	10815-10817
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	38
DOIs	https://doi.org/10.1039/c1cc14034e
State	Published - Oct 14 2011

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
Chemistry(all)

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abstract = "A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.",

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T1 - One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

AU - Chen, Yi

AU - Thon, Vireak

AU - Li, Yanhong

AU - Yu, Hai

AU - Ding, Li

AU - Lau, Kam

AU - Qu, Jingyao

AU - Hie, Liana

AU - Chen, Xi

PY - 2011/10/14

Y1 - 2011/10/14

N2 - A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

AB - A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 38

ER -

One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

Abstract

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