One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

Yi Chen, Vireak Thon, Yanhong Li, Hai Yu, Li Ding, Kam Lau, Jingyao Qu, Liana Hie, Xi Chen

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

Original languageEnglish (US)
Pages (from-to)10815-10817
Number of pages3
JournalChemical Communications
Volume47
Issue number38
DOIs
StatePublished - Oct 14 2011

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Inorganic Pyrophosphatase
Uridine Diphosphate
Phosphates
Phosphotransferases
Enzymes
Derivatives
N-acetylglucosamine-1-phosphate

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Chen, Y., Thon, V., Li, Y., Yu, H., Ding, L., Lau, K., ... Chen, X. (2011). One-pot three-enzyme synthesis of UDP-GlcNAc derivatives. Chemical Communications, 47(38), 10815-10817. https://doi.org/10.1039/c1cc14034e

One-pot three-enzyme synthesis of UDP-GlcNAc derivatives. / Chen, Yi; Thon, Vireak; Li, Yanhong; Yu, Hai; Ding, Li; Lau, Kam; Qu, Jingyao; Hie, Liana; Chen, Xi.

In: Chemical Communications, Vol. 47, No. 38, 14.10.2011, p. 10815-10817.

Research output: Contribution to journalArticle

Chen, Y, Thon, V, Li, Y, Yu, H, Ding, L, Lau, K, Qu, J, Hie, L & Chen, X 2011, 'One-pot three-enzyme synthesis of UDP-GlcNAc derivatives', Chemical Communications, vol. 47, no. 38, pp. 10815-10817. https://doi.org/10.1039/c1cc14034e
Chen Y, Thon V, Li Y, Yu H, Ding L, Lau K et al. One-pot three-enzyme synthesis of UDP-GlcNAc derivatives. Chemical Communications. 2011 Oct 14;47(38):10815-10817. https://doi.org/10.1039/c1cc14034e
Chen, Yi ; Thon, Vireak ; Li, Yanhong ; Yu, Hai ; Ding, Li ; Lau, Kam ; Qu, Jingyao ; Hie, Liana ; Chen, Xi. / One-pot three-enzyme synthesis of UDP-GlcNAc derivatives. In: Chemical Communications. 2011 ; Vol. 47, No. 38. pp. 10815-10817.
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