One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

Yi Chen, Vireak Thon, Yanhong Li, Hai Yu, Li Ding, Kam Lau, Jingyao Qu, Liana Hie, Xi Chen

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

Original languageEnglish (US)
Pages (from-to)10815-10817
Number of pages3
JournalChemical Communications
Volume47
Issue number38
DOIs
StatePublished - Oct 14 2011

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

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