One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies

Alex L. Bagdasarian; Huy H. Nguyen; Teresa A. Palazzo; James C. Fettinger; Makhluf J. Haddadin; Mark J. Kurth

doi:10.1021/acs.joc.6b00338

One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies

Alex L. Bagdasarian, Huy H. Nguyen, Teresa A. Palazzo, James C. Fettinger, Makhluf J. Haddadin, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.

Original language	English (US)
Pages (from-to)	3924-3928
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	81
Issue number	9
DOIs	https://doi.org/10.1021/acs.joc.6b00338
State	Published - May 6 2016

ASJC Scopus subject areas

Organic Chemistry

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10.1021/acs.joc.6b00338

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One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies. / Bagdasarian, Alex L.; Nguyen, Huy H.; Palazzo, Teresa A.; Fettinger, James C.; Haddadin, Makhluf J.; Kurth, Mark J.

In: Journal of Organic Chemistry, Vol. 81, No. 9, 06.05.2016, p. 3924-3928.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.",

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AU - Kurth, Mark J.

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