One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies

Alex L. Bagdasarian, Huy H. Nguyen, Teresa A. Palazzo, James C. Fettinger, Makhluf J. Haddadin, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.

Original languageEnglish (US)
Pages (from-to)3924-3928
Number of pages5
JournalJournal of Organic Chemistry
Volume81
Issue number9
DOIs
StatePublished - May 6 2016

ASJC Scopus subject areas

  • Organic Chemistry

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