'One-Pot' fabrication of highly versatile and biocompatible poly(vinyl alcohol)-porphyrin-based nanotheranostics

Yan Luo, Hao Wu, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-Yin Lin, Hongyong Zhang, Jeffrey H. Walton, Yousif Ajena, Yide Hu, Kit Lam, Yuanpei Li

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Nanoparticle-based theranostic agents have emerged as a new paradigm in nanomedicine field for integration of multimodal imaging and therapeutic functions within a single platform. However, the clinical translation of these agents is severely limited by the complexity of fabrication, long-term toxicity of the materials, and unfavorable biodistributions. Here we report an extremely simple and robust approach to develop highly versatile and biocompatible theranostic poly(vinyl alcohol)-porphyrin nanoparticles (PPNs). Through a "one-pot" fabrication process, including the chelation of metal ions and encapsulation of hydrophobic drugs, monodispersenanoparticle could be formed by self-assembly of a very simple and biocompatible building block (poly(vinyl alcohol)-porphyrin conjugate). Using this approach, we could conveniently produce multifunctional PPNs that integrate optical imaging, positron emission tomography (PET), photodynamic therapy (PDT), photothermal therapy (PTT) and drug delivery functions in one formulation. PPNs exhibited unique architecture-dependent fluorescence self-quenching, as well as photodynamic- and photothermal- properties. Near-infrared fluorescence could be amplified upon PPN dissociation, providing feasibility of low-background fluorescence imaging. Doxorubicin (DOX)-loaded PPNs achieved 53 times longer half-life in blood circulation than free DOX. Upon irradiation by near infrared light at a single excitation wavelength, PPNs could be activated to release reactive oxygen species, heat and drugs simultaneously at the tumor sites in mice bearing tumor xenograft, resulting in complete eradication of tumors. Due to their organic compositions, PPNs showed no obvious cytotoxicity in mice via intravenous administration during therapeutic studies. This highly versatile and multifunctional PPN theranostic nanoplatform showed great potential for the integration of multimodal imaging and therapeutic functions towards personalized nanomedicine against cancers.

Original languageEnglish (US)
Article number20190
JournalTheranostics
Volume7
Issue number16
DOIs
StatePublished - 2017

Fingerprint

Porphyrins
Nanoparticles
Alcohols
Multimodal Imaging
Nanomedicine
Optical Imaging
Doxorubicin
Neoplasms
Fluorescence
Blood Circulation
Photochemotherapy
Heterografts
Pharmaceutical Preparations
Intravenous Administration
Positron-Emission Tomography
Half-Life
Reactive Oxygen Species
Therapeutics
Hot Temperature
Metals

Keywords

  • 'One-pot' fabrication
  • Imaging
  • Multimodal therapy
  • Poly(vinyl alcohol)-porphyrin
  • Theranostics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

'One-Pot' fabrication of highly versatile and biocompatible poly(vinyl alcohol)-porphyrin-based nanotheranostics. / Luo, Yan; Wu, Hao; Feng, Caihong; Xiao, Kai; Yang, Xixiao; Liu, Qiangqiang; Lin, Tzu-Yin; Zhang, Hongyong; Walton, Jeffrey H.; Ajena, Yousif; Hu, Yide; Lam, Kit; Li, Yuanpei.

In: Theranostics, Vol. 7, No. 16, 20190, 2017.

Research output: Contribution to journalArticle

Luo, Y, Wu, H, Feng, C, Xiao, K, Yang, X, Liu, Q, Lin, T-Y, Zhang, H, Walton, JH, Ajena, Y, Hu, Y, Lam, K & Li, Y 2017, ''One-Pot' fabrication of highly versatile and biocompatible poly(vinyl alcohol)-porphyrin-based nanotheranostics', Theranostics, vol. 7, no. 16, 20190. https://doi.org/10.7150/thno.20190
Luo, Yan ; Wu, Hao ; Feng, Caihong ; Xiao, Kai ; Yang, Xixiao ; Liu, Qiangqiang ; Lin, Tzu-Yin ; Zhang, Hongyong ; Walton, Jeffrey H. ; Ajena, Yousif ; Hu, Yide ; Lam, Kit ; Li, Yuanpei. / 'One-Pot' fabrication of highly versatile and biocompatible poly(vinyl alcohol)-porphyrin-based nanotheranostics. In: Theranostics. 2017 ; Vol. 7, No. 16.
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