One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by 19F NMR rotating frame zeugmatography

Tsutomu Nakada; Ingrid Kwee

doi:10.1016/0730-725X(89)90408-6

One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by ¹⁹F NMR rotating frame zeugmatography

Tsutomu Nakada, Ingrid Kwee

Neurology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (¹⁹F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.

Original language	English (US)
Pages (from-to)	543-545
Number of pages	3
Journal	Magnetic Resonance Imaging
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/0730-725X(89)90408-6
State	Published - 1989

Keywords

F MRI
Fluphenazine
Neuroleptics
Receptor imaging
Trifluoperazine

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/0730-725X(89)90408-6

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title = "One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by 19F NMR rotating frame zeugmatography",

abstract = "One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.",

keywords = "F MRI, Fluphenazine, Neuroleptics, Receptor imaging, Trifluoperazine",

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AU - Kwee, Ingrid

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AB - One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.

KW - F MRI

KW - Fluphenazine

KW - Neuroleptics

KW - Receptor imaging

KW - Trifluoperazine

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