One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by 19F NMR rotating frame zeugmatography

Tsutomu Nakada, Ingrid Kwee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.

Original languageEnglish (US)
Pages (from-to)543-545
Number of pages3
JournalMagnetic Resonance Imaging
Volume7
Issue number5
DOIs
StatePublished - 1989

Fingerprint

Fluorine
Antipsychotic Agents
rats
brain
fluorine
chemical equilibrium
Rats
Brain
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Nuclear magnetic resonance
nuclear magnetic resonance
Tissue
Fluphenazine
neurotransmitters
Trifluoperazine
metabolites
Subcutaneous Tissue
Metabolites
Basal Ganglia

Keywords

  • F MRI
  • Fluphenazine
  • Neuroleptics
  • Receptor imaging
  • Trifluoperazine

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

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abstract = "One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.",
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N2 - One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.

AB - One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.

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KW - Neuroleptics

KW - Receptor imaging

KW - Trifluoperazine

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