Abstract
One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 543-545 |
| Number of pages | 3 |
| Journal | Magnetic Resonance Imaging |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1989 |
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Keywords
- F MRI
- Fluphenazine
- Neuroleptics
- Receptor imaging
- Trifluoperazine
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Cite this
One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by 19F NMR rotating frame zeugmatography. / Nakada, Tsutomu; Kwee, Ingrid.
In: Magnetic Resonance Imaging, Vol. 7, No. 5, 1989, p. 543-545.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by 19F NMR rotating frame zeugmatography
AU - Nakada, Tsutomu
AU - Kwee, Ingrid
PY - 1989
Y1 - 1989
N2 - One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.
AB - One-dimensional chemical shift imaging reflecting local tissue contents of the fluorinated neuroleptics fluphenazine and trifluoperazine in rat brain was obtained noninvasively in vivo using one-dimensional 19-fluorine (19F) nuclear magnetic resonance (NMR) rotating frame zeugmatography. Activities of these fluorinated neuroleptics showed a differential distribution in the brain, maximal in the deep structures presumably within the basal ganglia. An additional resonance of an unidentified fluorinated metabolite was localized to the subcutaneous tissue. The present data indicate the feasibility of chemical shift imaging of fluorinated neuroleptics using a high field NMR system and the potential for future development of neurotransmitter imaging by NMR.
KW - F MRI
KW - Fluphenazine
KW - Neuroleptics
KW - Receptor imaging
KW - Trifluoperazine
UR - http://www.scopus.com/inward/record.url?scp=0024429080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024429080&partnerID=8YFLogxK
U2 - 10.1016/0730-725X(89)90408-6
DO - 10.1016/0730-725X(89)90408-6
M3 - Article
C2 - 2575203
AN - SCOPUS:0024429080
VL - 7
SP - 543
EP - 545
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 5
ER -