Oncology applications: Intraoperative diagnosis of head and neck carcinoma

D Gregory Farwell, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingChapter


Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide (Howlader et al. 2011; Upile et al. 2009). The estimated new cases of oral cancer exceeded 40,000 in 2012 in the United States alone (NCI 2012). The known risk factors include chronic topical carcinogen exposure from tobacco, alcohol, and betel quid. Since these carcinogens are typically widely exposed to the tissues of the upper aerodigestive tract through smoke inhalation or alcohol ingestion, patients are predisposed to field cancerization and the development of new malignancies adjacent or remote to the initial tumor. A more recent association has been made in the oropharynx with remote high-risk HPV infection and DNA integration of viral oncogenes.

Original languageEnglish (US)
Title of host publicationFluorescence Lifetime Spectroscopy and Imaging
Subtitle of host publicationPrinciples and Applications in Biomedical Diagnostics
PublisherCRC Press
Number of pages11
ISBN (Electronic)9781439861684
ISBN (Print)9781439861677
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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