Oncologic safety of adipose-derived stem cell application

Hakan Orbay, David E. Sahar

Research output: Chapter in Book/Report/Conference proceedingChapter


Fat grafting is commonly used in postmastectomy breast reconstruction to correct contour irregularities and volume deficits. Early basic science studies documented the stimulatory effects of adipose-derived stem cells on breast cancer cells both in vitro and in vivo. However, this risk observed in experimental studies has not been observed in clinical studies. This chapter discusses conflicting experimental and clinical data on the oncologic safety of fat grafting, in addition to current clinical regulations on the use of fat grafts and adipose-derived stem cells.

Original languageEnglish (US)
Title of host publicationScientific Principles of Adipose Stem Cells
Number of pages8
ISBN (Electronic)9780128193761
StatePublished - Jan 1 2021


  • Adipose-derived mesenchymal stem cells
  • Breast cancer
  • Lipofilling
  • Metastasis
  • Recurrence

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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