Abstract
Reprocessing of a dialyzer for repeated use in the same patient is widely practiced. The dialyzer fiber bundle volume (FBV) is monitored as an indicator of the dialyzer's suitability for continued use, with standards for reprocessed dialyzers requiring a FBV of greater than 80% of a new dialyzer to be maintained. We have used on-line measurement of clearance of sodium (OLC module, Fresenius Medical Care, Walnut Creek, CA) to assess small molecule clearance changes during and between treatments for a group of 29 chronic hemodialysis patients who reused high flux polysulfone dialyzers (F80, Fresenius Medical Care, Lexington, MA) reprocessed using citric acid and heat (95°C). Data pertaining to the initial, 5th, 10th, and 15th uses were analyzed and showed that, within a single dialysis session, there was a trend for the clearance to reduce throughout the treatment (p < 0.001). Overall, there was also a trend for clearances to decline with increasing number of reuses (p < 0.008). Changes in FBV occurred, but such changes remained within the guidelines suggested by standards. It is concluded that on-line clearance measurements provide a simple noninvasive method to monitor dialyzer performance over each use and between uses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 543-546 |
| Number of pages | 4 |
| Journal | ASAIO Journal |
| Volume | 49 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Bioengineering
Cite this
On-line clearance : A useful tool for monitoring the effectiveness of the reuse procedure. / Rahmati, Margaret A.; Rahmati, Shahriar; Hoenich, Nicholas; Ronco, Claudio; Kaysen, George; Levin, Robert; Levine, Nathan W.
In: ASAIO Journal, Vol. 49, No. 5, 09.2003, p. 543-546.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On-line clearance
T2 - A useful tool for monitoring the effectiveness of the reuse procedure
AU - Rahmati, Margaret A.
AU - Rahmati, Shahriar
AU - Hoenich, Nicholas
AU - Ronco, Claudio
AU - Kaysen, George
AU - Levin, Robert
AU - Levine, Nathan W.
PY - 2003/9
Y1 - 2003/9
N2 - Reprocessing of a dialyzer for repeated use in the same patient is widely practiced. The dialyzer fiber bundle volume (FBV) is monitored as an indicator of the dialyzer's suitability for continued use, with standards for reprocessed dialyzers requiring a FBV of greater than 80% of a new dialyzer to be maintained. We have used on-line measurement of clearance of sodium (OLC module, Fresenius Medical Care, Walnut Creek, CA) to assess small molecule clearance changes during and between treatments for a group of 29 chronic hemodialysis patients who reused high flux polysulfone dialyzers (F80, Fresenius Medical Care, Lexington, MA) reprocessed using citric acid and heat (95°C). Data pertaining to the initial, 5th, 10th, and 15th uses were analyzed and showed that, within a single dialysis session, there was a trend for the clearance to reduce throughout the treatment (p < 0.001). Overall, there was also a trend for clearances to decline with increasing number of reuses (p < 0.008). Changes in FBV occurred, but such changes remained within the guidelines suggested by standards. It is concluded that on-line clearance measurements provide a simple noninvasive method to monitor dialyzer performance over each use and between uses.
AB - Reprocessing of a dialyzer for repeated use in the same patient is widely practiced. The dialyzer fiber bundle volume (FBV) is monitored as an indicator of the dialyzer's suitability for continued use, with standards for reprocessed dialyzers requiring a FBV of greater than 80% of a new dialyzer to be maintained. We have used on-line measurement of clearance of sodium (OLC module, Fresenius Medical Care, Walnut Creek, CA) to assess small molecule clearance changes during and between treatments for a group of 29 chronic hemodialysis patients who reused high flux polysulfone dialyzers (F80, Fresenius Medical Care, Lexington, MA) reprocessed using citric acid and heat (95°C). Data pertaining to the initial, 5th, 10th, and 15th uses were analyzed and showed that, within a single dialysis session, there was a trend for the clearance to reduce throughout the treatment (p < 0.001). Overall, there was also a trend for clearances to decline with increasing number of reuses (p < 0.008). Changes in FBV occurred, but such changes remained within the guidelines suggested by standards. It is concluded that on-line clearance measurements provide a simple noninvasive method to monitor dialyzer performance over each use and between uses.
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UR - http://www.scopus.com/inward/citedby.url?scp=0141702106&partnerID=8YFLogxK
U2 - 10.1097/01.MAT.0000084177.34517.9B
DO - 10.1097/01.MAT.0000084177.34517.9B
M3 - Article
C2 - 14524561
AN - SCOPUS:0141702106
VL - 49
SP - 543
EP - 546
JO - ASAIO Journal
JF - ASAIO Journal
SN - 1058-2916
IS - 5
ER -