Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice

Poonamjot Deol, Johannes Fahrmann, Jun Yang, Jane R. Evans, Antonia Rizo, Dmitry Grapov, Michelle Salemi, Kwanjeera Wanichthanarak, Oliver Fiehn, Brett Phinney, Bruce D. Hammock, Frances M. Sladek

Research output: Contribution to journalArticle

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Abstract

Soybean oil consumption is increasing worldwide and parallels a rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance, and fatty liver in mice. Here, we show that the genetically modified soybean oil Plenish, which came on the U.S. market in 2014 and is low in linoleic acid, induces less obesity than conventional soybean oil in C57BL/6 male mice. Proteomic analysis of the liver reveals global differences in hepatic proteins when comparing diets rich in the two soybean oils, coconut oil, and a low-fat diet. Metabolomic analysis of the liver and plasma shows a positive correlation between obesity and hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway. While Plenish induced less insulin resistance than conventional soybean oil, it resulted in hepatomegaly and liver dysfunction as did olive oil, which has a similar fatty acid composition. These results implicate a new class of compounds in diet-induced obesity-C18 epoxide and diol oxylipins.

Original languageEnglish (US)
Article number12488
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Oxylipins
Soybean Oil
Obesity
Liver
Linoleic Acid
Insulin Resistance
Fatty Acids
Unsaturated Fats
Diet
Epoxide Hydrolases
Fat-Restricted Diet
Metabolomics
Hepatomegaly
Epoxy Compounds
Fatty Liver
Proteomics
Cytochrome P-450 Enzyme System
Liver Diseases

ASJC Scopus subject areas

  • General

Cite this

Deol, P., Fahrmann, J., Yang, J., Evans, J. R., Rizo, A., Grapov, D., ... Sladek, F. M. (2017). Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Scientific Reports, 7(1), [12488]. https://doi.org/10.1038/s41598-017-12624-9

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. / Deol, Poonamjot; Fahrmann, Johannes; Yang, Jun; Evans, Jane R.; Rizo, Antonia; Grapov, Dmitry; Salemi, Michelle; Wanichthanarak, Kwanjeera; Fiehn, Oliver; Phinney, Brett; Hammock, Bruce D.; Sladek, Frances M.

In: Scientific Reports, Vol. 7, No. 1, 12488, 01.12.2017.

Research output: Contribution to journalArticle

Deol, P, Fahrmann, J, Yang, J, Evans, JR, Rizo, A, Grapov, D, Salemi, M, Wanichthanarak, K, Fiehn, O, Phinney, B, Hammock, BD & Sladek, FM 2017, 'Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice', Scientific Reports, vol. 7, no. 1, 12488. https://doi.org/10.1038/s41598-017-12624-9
Deol, Poonamjot ; Fahrmann, Johannes ; Yang, Jun ; Evans, Jane R. ; Rizo, Antonia ; Grapov, Dmitry ; Salemi, Michelle ; Wanichthanarak, Kwanjeera ; Fiehn, Oliver ; Phinney, Brett ; Hammock, Bruce D. ; Sladek, Frances M. / Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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