Oligonucleotide delivery by cell-penetrating "striped" nanoparticles

Christopher M. Jewell, Jin Mi Jung, Prabhani U. Atukorale, Randy Carney, Francesco Stellacci, Darrell J. Irvine

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

Original languageEnglish (US)
Pages (from-to)12312-12315
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number51
DOIs
StatePublished - Dec 16 2011
Externally publishedYes

Keywords

  • DNA delivery
  • endocytosis
  • gene therapy
  • gold nanoparticles
  • ligands (organic)

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint

Dive into the research topics of 'Oligonucleotide delivery by cell-penetrating "striped" nanoparticles'. Together they form a unique fingerprint.

Cite this