Oligonucleotide delivery by cell-penetrating "striped" nanoparticles

Christopher M. Jewell, Jin Mi Jung, Prabhani U. Atukorale, Randy Carney, Francesco Stellacci, Darrell J. Irvine

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

Original languageEnglish (US)
Pages (from-to)12312-12315
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number51
DOIs
StatePublished - Dec 16 2011
Externally publishedYes

Fingerprint

Oligonucleotides
DNA
Nanoparticles
Ligands
Single-Stranded DNA
Gold
Tumors
Cells

Keywords

  • DNA delivery
  • endocytosis
  • gene therapy
  • gold nanoparticles
  • ligands (organic)

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Jewell, C. M., Jung, J. M., Atukorale, P. U., Carney, R., Stellacci, F., & Irvine, D. J. (2011). Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. Angewandte Chemie - International Edition, 50(51), 12312-12315. https://doi.org/10.1002/anie.201104514

Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. / Jewell, Christopher M.; Jung, Jin Mi; Atukorale, Prabhani U.; Carney, Randy; Stellacci, Francesco; Irvine, Darrell J.

In: Angewandte Chemie - International Edition, Vol. 50, No. 51, 16.12.2011, p. 12312-12315.

Research output: Contribution to journalArticle

Jewell, CM, Jung, JM, Atukorale, PU, Carney, R, Stellacci, F & Irvine, DJ 2011, 'Oligonucleotide delivery by cell-penetrating "striped" nanoparticles', Angewandte Chemie - International Edition, vol. 50, no. 51, pp. 12312-12315. https://doi.org/10.1002/anie.201104514
Jewell, Christopher M. ; Jung, Jin Mi ; Atukorale, Prabhani U. ; Carney, Randy ; Stellacci, Francesco ; Irvine, Darrell J. / Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 51. pp. 12312-12315.
@article{df412ad4e8d24b2782760dcc10dcd73e,
title = "Oligonucleotide delivery by cell-penetrating {"}striped{"} nanoparticles",
abstract = "Gold nanoparticles coated with homogeneous (MUS) or {"}striped{"} (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.",
keywords = "DNA delivery, endocytosis, gene therapy, gold nanoparticles, ligands (organic)",
author = "Jewell, {Christopher M.} and Jung, {Jin Mi} and Atukorale, {Prabhani U.} and Randy Carney and Francesco Stellacci and Irvine, {Darrell J.}",
year = "2011",
month = "12",
day = "16",
doi = "10.1002/anie.201104514",
language = "English (US)",
volume = "50",
pages = "12312--12315",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "51",

}

TY - JOUR

T1 - Oligonucleotide delivery by cell-penetrating "striped" nanoparticles

AU - Jewell, Christopher M.

AU - Jung, Jin Mi

AU - Atukorale, Prabhani U.

AU - Carney, Randy

AU - Stellacci, Francesco

AU - Irvine, Darrell J.

PY - 2011/12/16

Y1 - 2011/12/16

N2 - Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

AB - Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

KW - DNA delivery

KW - endocytosis

KW - gene therapy

KW - gold nanoparticles

KW - ligands (organic)

UR - http://www.scopus.com/inward/record.url?scp=83755194708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83755194708&partnerID=8YFLogxK

U2 - 10.1002/anie.201104514

DO - 10.1002/anie.201104514

M3 - Article

C2 - 22028047

AN - SCOPUS:83755194708

VL - 50

SP - 12312

EP - 12315

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 51

ER -