Oligonucleotide delivery by cell-penetrating "striped" nanoparticles

Christopher M. Jewell, Jin Mi Jung, Prabhani U. Atukorale, Randy Carney, Francesco Stellacci, Darrell J. Irvine

Research output: Contribution to journalArticle

57 Scopus citations


Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

Original languageEnglish (US)
Pages (from-to)12312-12315
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number51
StatePublished - Dec 16 2011
Externally publishedYes


  • DNA delivery
  • endocytosis
  • gene therapy
  • gold nanoparticles
  • ligands (organic)

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Oligonucleotide delivery by cell-penetrating "striped" nanoparticles'. Together they form a unique fingerprint.

  • Cite this

    Jewell, C. M., Jung, J. M., Atukorale, P. U., Carney, R., Stellacci, F., & Irvine, D. J. (2011). Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. Angewandte Chemie - International Edition, 50(51), 12312-12315. https://doi.org/10.1002/anie.201104514