Oligodendrocyte differentiation and myelination defects in OMgp null mice

Xinhua Lee, Yinghui Hu, Yiping Zhang, Zhongshu Yang, Zhaohui Shao, Mengsheng Qiu, Blake Pepinsky, Robert H. Miller, Sha Mi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

OMgp is selectively expressed in CNS by oligodendrocyte. However, its potential role(s) in oligodendrocyte development and myelination remain unclear. We show that OMgp null mice are hypomyelinated in their spinal cords, resulting in slower ascending and descending conduction velocities compared to wild-type mice. Consistent with the hypomyelination, in the MOG induced EAE model, OMgp null mice show a more severe EAE clinical disease and slower nerve conduction velocity compared to WT animals. The contribution of OMgp to oligodendrocyte differentiation and myelination was verified using cultured oligodendrocytes from null mice. Oligodendrocytes isolated from OMgp null mice show a significant decrease in the number of MBP+ cells and in myelination compared to wild-type mice. The dramatic effects of the OMgp KO in oligodendrocyte maturation in vivo and in vitro reveal a new and important function for OMgp in regulating CNS myelination.

Original languageEnglish (US)
Pages (from-to)752-761
Number of pages10
JournalMolecular and Cellular Neuroscience
Volume46
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • CNS
  • Myelination
  • Oligodendrocryte differentiation
  • OMgp

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Fingerprint Dive into the research topics of 'Oligodendrocyte differentiation and myelination defects in OMgp null mice'. Together they form a unique fingerprint.

  • Cite this

    Lee, X., Hu, Y., Zhang, Y., Yang, Z., Shao, Z., Qiu, M., Pepinsky, B., Miller, R. H., & Mi, S. (2011). Oligodendrocyte differentiation and myelination defects in OMgp null mice. Molecular and Cellular Neuroscience, 46(4), 752-761. https://doi.org/10.1016/j.mcn.2011.02.008