Oligoclonal IgG in the cerebrospinal fluid of guinea pigs with acute experimental allergic encephalomyelitis

Abdolmohammad Rostami, Robert P. Lisak, Nadine Blanchard, Felicula Guerrero, Burton Zweiman, David E Pleasure

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The cerebrospinal fluid (CSF) of guinea pigs with experimental allergic encephalomyelitis was examined for the presence of oligoclonal IgG using polyacrylamide gel electrophoresis. Oligoclonal IgG (≥2 bands) was seen in the CSF obtained from 3 4 animals with experimental allergic encephalomyelitis induced by myelin basic protein and 2 3 with spinal cord-induced disease. It was not seen in CSF of 3 non-sensitized, 4 adjuvant-sensitized and 7 liver-sensitized guinea pigs. Scanning of stained gels confirmed the oligoclonal pattern. The bands were found in the region of gels which bound [125I]Staphylococcal Protein A. The data demonstrate that a non-infectious inflammatory reaction within the central nervous system can result in an oligoclonal IgG pattern in the CSF.

Original languageEnglish (US)
Pages (from-to)433-441
Number of pages9
JournalJournal of the Neurological Sciences
Volume53
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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