Olfactory sensory neuron-specific and sexually dimorphic expression of protocadherin 20

Wooje Lee, Ting Wen Cheng, Qizhi Gong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Olfactory sensory axons navigate from the nasal cavity to the olfactory bulb and sort from among 1,000 different odorant receptor-expressing types to converge upon the same two or three glomeruli. To achieve this task during development, it is likely that multiple classes of regulatory molecules, including cell adhesion molecules, are involved. Cell adhesion molecules have been shown to be important in controlling axon guidance, fasciculation, and synapse formation. To gain further understanding of the involvement of adhesion molecules in olfactory circuitry development, we examined the dynamic and cell type specific expression of a novel protocadherin, PCDH20, in the olfactory system. PCDH20 is specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. PCDH20 expression is down-regulated in the adult olfactory system, except in a small olfactory sensory neuron population. These small, discrete numbers of PCDH20-positive glomeruli in the adult olfactory bulb are consistently clustered in the ventral-caudal region in both male and female mice. However, adult males have higher numbers of PCDH20-positive glomeruli with a broader distribution, whereas adult females have fewer PCDH20-positive glomeruli with a more restricted distribution. The gender difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-specific social discrimination.

Original languageEnglish (US)
Pages (from-to)1076-1086
Number of pages11
JournalJournal of Comparative Neurology
Volume507
Issue number1
DOIs
StatePublished - Mar 1 2008

Fingerprint

Odorant Receptors
Olfactory Receptor Neurons
Olfactory Bulb
Cell Adhesion Molecules
Axons
Social Discrimination
Nasal Cavity
Synapses
Population

Keywords

  • Anterior pituitary
  • Diphtheria toxin receptor
  • Glomerulus
  • Olfaction
  • Pancreas
  • Vomeronasal organ

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Olfactory sensory neuron-specific and sexually dimorphic expression of protocadherin 20. / Lee, Wooje; Cheng, Ting Wen; Gong, Qizhi.

In: Journal of Comparative Neurology, Vol. 507, No. 1, 01.03.2008, p. 1076-1086.

Research output: Contribution to journalArticle

@article{863d884ebc3a47fb9b82911e53aaa4d2,
title = "Olfactory sensory neuron-specific and sexually dimorphic expression of protocadherin 20",
abstract = "Olfactory sensory axons navigate from the nasal cavity to the olfactory bulb and sort from among 1,000 different odorant receptor-expressing types to converge upon the same two or three glomeruli. To achieve this task during development, it is likely that multiple classes of regulatory molecules, including cell adhesion molecules, are involved. Cell adhesion molecules have been shown to be important in controlling axon guidance, fasciculation, and synapse formation. To gain further understanding of the involvement of adhesion molecules in olfactory circuitry development, we examined the dynamic and cell type specific expression of a novel protocadherin, PCDH20, in the olfactory system. PCDH20 is specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. PCDH20 expression is down-regulated in the adult olfactory system, except in a small olfactory sensory neuron population. These small, discrete numbers of PCDH20-positive glomeruli in the adult olfactory bulb are consistently clustered in the ventral-caudal region in both male and female mice. However, adult males have higher numbers of PCDH20-positive glomeruli with a broader distribution, whereas adult females have fewer PCDH20-positive glomeruli with a more restricted distribution. The gender difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-specific social discrimination.",
keywords = "Anterior pituitary, Diphtheria toxin receptor, Glomerulus, Olfaction, Pancreas, Vomeronasal organ",
author = "Wooje Lee and Cheng, {Ting Wen} and Qizhi Gong",
year = "2008",
month = "3",
day = "1",
doi = "10.1002/cne.21569",
language = "English (US)",
volume = "507",
pages = "1076--1086",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Olfactory sensory neuron-specific and sexually dimorphic expression of protocadherin 20

AU - Lee, Wooje

AU - Cheng, Ting Wen

AU - Gong, Qizhi

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Olfactory sensory axons navigate from the nasal cavity to the olfactory bulb and sort from among 1,000 different odorant receptor-expressing types to converge upon the same two or three glomeruli. To achieve this task during development, it is likely that multiple classes of regulatory molecules, including cell adhesion molecules, are involved. Cell adhesion molecules have been shown to be important in controlling axon guidance, fasciculation, and synapse formation. To gain further understanding of the involvement of adhesion molecules in olfactory circuitry development, we examined the dynamic and cell type specific expression of a novel protocadherin, PCDH20, in the olfactory system. PCDH20 is specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. PCDH20 expression is down-regulated in the adult olfactory system, except in a small olfactory sensory neuron population. These small, discrete numbers of PCDH20-positive glomeruli in the adult olfactory bulb are consistently clustered in the ventral-caudal region in both male and female mice. However, adult males have higher numbers of PCDH20-positive glomeruli with a broader distribution, whereas adult females have fewer PCDH20-positive glomeruli with a more restricted distribution. The gender difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-specific social discrimination.

AB - Olfactory sensory axons navigate from the nasal cavity to the olfactory bulb and sort from among 1,000 different odorant receptor-expressing types to converge upon the same two or three glomeruli. To achieve this task during development, it is likely that multiple classes of regulatory molecules, including cell adhesion molecules, are involved. Cell adhesion molecules have been shown to be important in controlling axon guidance, fasciculation, and synapse formation. To gain further understanding of the involvement of adhesion molecules in olfactory circuitry development, we examined the dynamic and cell type specific expression of a novel protocadherin, PCDH20, in the olfactory system. PCDH20 is specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. PCDH20 expression is down-regulated in the adult olfactory system, except in a small olfactory sensory neuron population. These small, discrete numbers of PCDH20-positive glomeruli in the adult olfactory bulb are consistently clustered in the ventral-caudal region in both male and female mice. However, adult males have higher numbers of PCDH20-positive glomeruli with a broader distribution, whereas adult females have fewer PCDH20-positive glomeruli with a more restricted distribution. The gender difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-specific social discrimination.

KW - Anterior pituitary

KW - Diphtheria toxin receptor

KW - Glomerulus

KW - Olfaction

KW - Pancreas

KW - Vomeronasal organ

UR - http://www.scopus.com/inward/record.url?scp=38949139480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38949139480&partnerID=8YFLogxK

U2 - 10.1002/cne.21569

DO - 10.1002/cne.21569

M3 - Article

VL - 507

SP - 1076

EP - 1086

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 1

ER -