Olfactory identification deficits and MCI in a multi-ethnic elderly community sample

D. P. Devanand, Matthias H. Tabert, Katrina Cuasay, Jennifer J. Manly, Nicole Schupf, Adam M. Brickman, Howard Andrews, Truman R. Brown, Charles DeCarli, Richard Mayeux

Research output: Contribution to journalArticle

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Abstract

Odor identification deficits occur in Alzheimer's disease (AD) and mild cognitive impairment (MCI), and predict clinical conversion from MCI to AD. In an epidemiologic study conducted in a multi-ethnic community elderly sample (average 80 years old), the University of Pennsylvania Smell Identification Test (UPSIT, range 0-40) was administered to 1092 non-demented subjects. Women (mean 26.6, S.D. 6.6) scored higher than men (mean 24.4, S.D. 7.4, p<02), and ethnic differences were not significant after controlling for age and education. UPSIT scores correlated inversely with age (r=. -0.24, p<0001) and positively with Selective Reminding Test immediate recall (r=. 0.33), delayed recall (r=. 0.28), category fluency (r=. 0.28) and the 15-item Boston Naming Test (r=. 0.23), all ps <0001. In a sub-sample in which MRI was done, UPSIT scores showed a significant correlation with hippocampal volume (n=. 571, r=. 0.16, p<001) but not entorhinal cortex volume nor total number of white matter hyperintensities. In ANOVA, UPSIT scores differed (p<0001) as a function of MCI classification: no MCI (mean 26.6, S.D. 6.8), non-amnestic MCI (mean 24.4, S.D. 7.2), and amnestic MCI (mean 23.5, S.D. 6.7). The difference between amnestic MCI and no MCI remained significant after controlling for relevant covariates. These findings indicate that the predictive utility of olfactory identification deficits for decline from no MCI to MCI and AD needs to be assessed in longitudinal studies of elderly community samples.

Original languageEnglish (US)
Pages (from-to)1593-1600
Number of pages8
JournalNeurobiology of Aging
Volume31
Issue number9
DOIs
StatePublished - Sep 2010

Fingerprint

Alzheimer Disease
Cognitive Dysfunction
Entorhinal Cortex
Smell
Short-Term Memory
Longitudinal Studies
Epidemiologic Studies
Analysis of Variance
Education
Odorants
White Matter

Keywords

  • Entorhinal cortex volume
  • Epidemiology
  • Ethnicity
  • Hippocampal volume
  • Mild cognitive impairment
  • Olfaction
  • Verbal recall

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Devanand, D. P., Tabert, M. H., Cuasay, K., Manly, J. J., Schupf, N., Brickman, A. M., ... Mayeux, R. (2010). Olfactory identification deficits and MCI in a multi-ethnic elderly community sample. Neurobiology of Aging, 31(9), 1593-1600. https://doi.org/10.1016/j.neurobiolaging.2008.09.008

Olfactory identification deficits and MCI in a multi-ethnic elderly community sample. / Devanand, D. P.; Tabert, Matthias H.; Cuasay, Katrina; Manly, Jennifer J.; Schupf, Nicole; Brickman, Adam M.; Andrews, Howard; Brown, Truman R.; DeCarli, Charles; Mayeux, Richard.

In: Neurobiology of Aging, Vol. 31, No. 9, 09.2010, p. 1593-1600.

Research output: Contribution to journalArticle

Devanand, DP, Tabert, MH, Cuasay, K, Manly, JJ, Schupf, N, Brickman, AM, Andrews, H, Brown, TR, DeCarli, C & Mayeux, R 2010, 'Olfactory identification deficits and MCI in a multi-ethnic elderly community sample', Neurobiology of Aging, vol. 31, no. 9, pp. 1593-1600. https://doi.org/10.1016/j.neurobiolaging.2008.09.008
Devanand, D. P. ; Tabert, Matthias H. ; Cuasay, Katrina ; Manly, Jennifer J. ; Schupf, Nicole ; Brickman, Adam M. ; Andrews, Howard ; Brown, Truman R. ; DeCarli, Charles ; Mayeux, Richard. / Olfactory identification deficits and MCI in a multi-ethnic elderly community sample. In: Neurobiology of Aging. 2010 ; Vol. 31, No. 9. pp. 1593-1600.
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