Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus

Philip V. Holmes, Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.

Original languageEnglish (US)
Pages (from-to)184-188
Number of pages5
JournalMolecular Brain Research
Volume36
Issue number1
DOIs
StatePublished - Feb 1996
Externally publishedYes

Keywords

  • Galanin
  • In situ hybridization
  • Locus coeruleus
  • Messenger RNA
  • Neuropeptide Y
  • Olfactory bulb
  • Trophic factors
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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