Abstract
The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 184-188 |
| Number of pages | 5 |
| Journal | Molecular Brain Research |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1996 |
| Externally published | Yes |
Keywords
- Galanin
- In situ hybridization
- Locus coeruleus
- Messenger RNA
- Neuropeptide Y
- Olfactory bulb
- Trophic factors
- Tyrosine hydroxylase
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
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Cite this
Holmes, P. V., & Crawley, J. (1996). Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus. Molecular Brain Research, 36(1), 184-188. https://doi.org/10.1016/0169-328X(95)00295-4