Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus

Philip V. Holmes; Jacqueline Crawley

doi:10.1016/0169-328X(95)00295-4

Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus

Philip V. Holmes, Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.

Original language	English (US)
Pages (from-to)	184-188
Number of pages	5
Journal	Molecular Brain Research
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(95)00295-4
State	Published - Feb 1996
Externally published	Yes

Keywords

Galanin
In situ hybridization
Locus coeruleus
Messenger RNA
Neuropeptide Y
Olfactory bulb
Trophic factors
Tyrosine hydroxylase

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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abstract = "The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.",

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AU - Holmes, Philip V.

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AB - The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.

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KW - Olfactory bulb

KW - Trophic factors

KW - Tyrosine hydroxylase

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Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus

Abstract

Keywords

ASJC Scopus subject areas

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