Abstract
Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.
Original language | English (US) |
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Pages (from-to) | 7117-7126 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 10 |
DOIs | |
State | Published - Mar 8 2013 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology