Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

Ji Hong Lim; Zachary Gerhart-Hines; John E. Dominy; Yoonjin Lee; Sungjin Kim; Mitsuhisa Tabata; Yang Kevin Xiang; Pere Puigserver

doi:10.1074/jbc.M112.415729

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

Ji Hong Lim, Zachary Gerhart-Hines, John E. Dominy, Yoonjin Lee, Sungjin Kim, Mitsuhisa Tabata, Yang Kevin Xiang, Pere Puigserver

Pharmacology

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

Original language	English (US)
Pages (from-to)	7117-7126
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M112.415729
State	Published - Mar 8 2013

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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10.1074/jbc.M112.415729

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Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. / Lim, Ji Hong; Gerhart-Hines, Zachary; Dominy, John E.; Lee, Yoonjin; Kim, Sungjin; Tabata, Mitsuhisa; Xiang, Yang Kevin; Puigserver, Pere.

In: Journal of Biological Chemistry, Vol. 288, No. 10, 08.03.2013, p. 7117-7126.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.",

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AU - Gerhart-Hines, Zachary

AU - Dominy, John E.

AU - Lee, Yoonjin

AU - Kim, Sungjin

AU - Tabata, Mitsuhisa

AU - Xiang, Yang Kevin

AU - Puigserver, Pere

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

AB - Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

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Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

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