Abstract
Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7117-7126 |
| Number of pages | 10 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 10 |
| DOIs | |
| State | Published - Mar 8 2013 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
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Lim, J. H., Gerhart-Hines, Z., Dominy, J. E., Lee, Y., Kim, S., Tabata, M., Xiang, Y. K., & Puigserver, P. (2013). Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. Journal of Biological Chemistry, 288(10), 7117-7126. https://doi.org/10.1074/jbc.M112.415729