Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

Ji Hong Lim; Zachary Gerhart-Hines; John E. Dominy; Yoonjin Lee; Sungjin Kim; Mitsuhisa Tabata; Yang Kevin Xiang; Pere Puigserver

doi:10.1074/jbc.M112.415729

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

Ji Hong Lim, Zachary Gerhart-Hines, John E. Dominy, Yoonjin Lee, Sungjin Kim, Mitsuhisa Tabata, Yang Kevin Xiang, Pere Puigserver

Pharmacology

Research output: Contribution to journal › Article

83 Scopus citations

Abstract

Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

Original language	English (US)
Pages (from-to)	7117-7126
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M112.415729
State	Published - Mar 8 2013

Fingerprint

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

Cite this

Lim, J. H., Gerhart-Hines, Z., Dominy, J. E., Lee, Y., Kim, S., Tabata, M., Xiang, Y. K., & Puigserver, P. (2013). Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. Journal of Biological Chemistry, 288(10), 7117-7126. https://doi.org/10.1074/jbc.M112.415729

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. / Lim, Ji Hong; Gerhart-Hines, Zachary; Dominy, John E.; Lee, Yoonjin; Kim, Sungjin; Tabata, Mitsuhisa; Xiang, Yang Kevin; Puigserver, Pere.

In: Journal of Biological Chemistry, Vol. 288, No. 10, 08.03.2013, p. 7117-7126.

Research output: Contribution to journal › Article

@article{ab6c749378114a3eae6dbf11d246a09b,

title = "Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex",

abstract = "Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.",

author = "Lim, {Ji Hong} and Zachary Gerhart-Hines and Dominy, {John E.} and Yoonjin Lee and Sungjin Kim and Mitsuhisa Tabata and Xiang, {Yang Kevin} and Pere Puigserver",

year = "2013",

month = mar

day = "8",

doi = "10.1074/jbc.M112.415729",

language = "English (US)",

volume = "288",

pages = "7117--7126",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "10",

}

TY - JOUR

T1 - Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

AU - Lim, Ji Hong

AU - Gerhart-Hines, Zachary

AU - Dominy, John E.

AU - Lee, Yoonjin

AU - Kim, Sungjin

AU - Tabata, Mitsuhisa

AU - Xiang, Yang Kevin

AU - Puigserver, Pere

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

AB - Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

UR - http://www.scopus.com/inward/record.url?scp=84874817589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874817589&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.415729

DO - 10.1074/jbc.M112.415729

M3 - Article

C2 - 23329830

AN - SCOPUS:84874817589

VL - 288

SP - 7117

EP - 7126

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 10

ER -

Access to Document

10.1074/jbc.M112.415729