Oleander toxicosis in equids: 30 cases (1995-2010)

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective-To determine clinical, laboratory analysis, and necropsy findings for equids with oleander toxicosis and to identify factors associated with outcome. Design-Retrospective case series. Animals-30 equids. Procedures-Medical records of equids with detectable concentrations of oleandrin in serum, plasma, urine, or gastrointestinal fluid samples and equids that had not received cardiac glycoside drugs but had detectable concentrations of digoxin in serum were identified via a medical records database search. Descriptive statistics were calculated for medical history, physical examination, laboratory analysis, and necropsy variables. Logistic regression analysis was used to identify physical examination and laboratory analysis factors significantly associated with outcome. Results-3 of 30 (10.0%) equids died before or immediately after arrival at the hospital. Of the other 27 equids, 23 (85.2%) had gastrointestinal tract abnormalities, azotemia was detected for 19 (70.4%), and a cardiac arrhythmia was ausculted for 18 (66.7%). Mortality rate for all equids was 50.0%; mortality rate for hospitalized equids was 44.4%. The most common cause of death was cardiac dysfunction. Odds of survival to discharge from the hospital were lower for equids with cardiac arrhythmias versus those without arrhythmias and decreased with increasing Hct and serum glucose concentrations. Odds of survival increased with increasing serum chloride concentration and duration of hospitalization. Conclusions and Clinical Relevance-Equids with oleander toxicosis frequently had simultaneous gastrointestinal tract, cardiac, and renal problems. Oleander intoxication should be a differential diagnosis for equids with colic in geographic areas where oleander is found, especially when azotemia or cardiac arrhythmias are detected concurrently.

Original languageEnglish (US)
Pages (from-to)540-549
Number of pages10
JournalJournal of the American Veterinary Medical Association
Volume242
Issue number4
DOIs
StatePublished - 2013

Fingerprint

Nerium
Nerium oleander
arrhythmia
Cardiac Arrhythmias
poisoning
Azotemia
uremia
Serum
clinical examination
Physical Examination
gastrointestinal system
Medical Records
Gastrointestinal Tract
necropsy
digoxin
cardiac glycosides
medical history
Cardiac Glycosides
Colic
Mortality

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{0a9335fac72f4a9a93e7a040602b1c21,
title = "Oleander toxicosis in equids: 30 cases (1995-2010)",
abstract = "Objective-To determine clinical, laboratory analysis, and necropsy findings for equids with oleander toxicosis and to identify factors associated with outcome. Design-Retrospective case series. Animals-30 equids. Procedures-Medical records of equids with detectable concentrations of oleandrin in serum, plasma, urine, or gastrointestinal fluid samples and equids that had not received cardiac glycoside drugs but had detectable concentrations of digoxin in serum were identified via a medical records database search. Descriptive statistics were calculated for medical history, physical examination, laboratory analysis, and necropsy variables. Logistic regression analysis was used to identify physical examination and laboratory analysis factors significantly associated with outcome. Results-3 of 30 (10.0{\%}) equids died before or immediately after arrival at the hospital. Of the other 27 equids, 23 (85.2{\%}) had gastrointestinal tract abnormalities, azotemia was detected for 19 (70.4{\%}), and a cardiac arrhythmia was ausculted for 18 (66.7{\%}). Mortality rate for all equids was 50.0{\%}; mortality rate for hospitalized equids was 44.4{\%}. The most common cause of death was cardiac dysfunction. Odds of survival to discharge from the hospital were lower for equids with cardiac arrhythmias versus those without arrhythmias and decreased with increasing Hct and serum glucose concentrations. Odds of survival increased with increasing serum chloride concentration and duration of hospitalization. Conclusions and Clinical Relevance-Equids with oleander toxicosis frequently had simultaneous gastrointestinal tract, cardiac, and renal problems. Oleander intoxication should be a differential diagnosis for equids with colic in geographic areas where oleander is found, especially when azotemia or cardiac arrhythmias are detected concurrently.",
author = "Renier, {Anna C.} and Kass, {Philip H} and Magdesian, {K G} and Madigan, {John E} and Aleman, {Monica R} and Nicola Pusterla",
year = "2013",
doi = "10.2460/javma.242.4.540",
language = "English (US)",
volume = "242",
pages = "540--549",
journal = "Journal of the American Veterinary Medical Association",
issn = "0003-1488",
publisher = "American Veterinary Medical Association",
number = "4",

}

TY - JOUR

T1 - Oleander toxicosis in equids

T2 - 30 cases (1995-2010)

AU - Renier, Anna C.

AU - Kass, Philip H

AU - Magdesian, K G

AU - Madigan, John E

AU - Aleman, Monica R

AU - Pusterla, Nicola

PY - 2013

Y1 - 2013

N2 - Objective-To determine clinical, laboratory analysis, and necropsy findings for equids with oleander toxicosis and to identify factors associated with outcome. Design-Retrospective case series. Animals-30 equids. Procedures-Medical records of equids with detectable concentrations of oleandrin in serum, plasma, urine, or gastrointestinal fluid samples and equids that had not received cardiac glycoside drugs but had detectable concentrations of digoxin in serum were identified via a medical records database search. Descriptive statistics were calculated for medical history, physical examination, laboratory analysis, and necropsy variables. Logistic regression analysis was used to identify physical examination and laboratory analysis factors significantly associated with outcome. Results-3 of 30 (10.0%) equids died before or immediately after arrival at the hospital. Of the other 27 equids, 23 (85.2%) had gastrointestinal tract abnormalities, azotemia was detected for 19 (70.4%), and a cardiac arrhythmia was ausculted for 18 (66.7%). Mortality rate for all equids was 50.0%; mortality rate for hospitalized equids was 44.4%. The most common cause of death was cardiac dysfunction. Odds of survival to discharge from the hospital were lower for equids with cardiac arrhythmias versus those without arrhythmias and decreased with increasing Hct and serum glucose concentrations. Odds of survival increased with increasing serum chloride concentration and duration of hospitalization. Conclusions and Clinical Relevance-Equids with oleander toxicosis frequently had simultaneous gastrointestinal tract, cardiac, and renal problems. Oleander intoxication should be a differential diagnosis for equids with colic in geographic areas where oleander is found, especially when azotemia or cardiac arrhythmias are detected concurrently.

AB - Objective-To determine clinical, laboratory analysis, and necropsy findings for equids with oleander toxicosis and to identify factors associated with outcome. Design-Retrospective case series. Animals-30 equids. Procedures-Medical records of equids with detectable concentrations of oleandrin in serum, plasma, urine, or gastrointestinal fluid samples and equids that had not received cardiac glycoside drugs but had detectable concentrations of digoxin in serum were identified via a medical records database search. Descriptive statistics were calculated for medical history, physical examination, laboratory analysis, and necropsy variables. Logistic regression analysis was used to identify physical examination and laboratory analysis factors significantly associated with outcome. Results-3 of 30 (10.0%) equids died before or immediately after arrival at the hospital. Of the other 27 equids, 23 (85.2%) had gastrointestinal tract abnormalities, azotemia was detected for 19 (70.4%), and a cardiac arrhythmia was ausculted for 18 (66.7%). Mortality rate for all equids was 50.0%; mortality rate for hospitalized equids was 44.4%. The most common cause of death was cardiac dysfunction. Odds of survival to discharge from the hospital were lower for equids with cardiac arrhythmias versus those without arrhythmias and decreased with increasing Hct and serum glucose concentrations. Odds of survival increased with increasing serum chloride concentration and duration of hospitalization. Conclusions and Clinical Relevance-Equids with oleander toxicosis frequently had simultaneous gastrointestinal tract, cardiac, and renal problems. Oleander intoxication should be a differential diagnosis for equids with colic in geographic areas where oleander is found, especially when azotemia or cardiac arrhythmias are detected concurrently.

UR - http://www.scopus.com/inward/record.url?scp=84873257761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873257761&partnerID=8YFLogxK

U2 - 10.2460/javma.242.4.540

DO - 10.2460/javma.242.4.540

M3 - Article

C2 - 23363288

AN - SCOPUS:84873257761

VL - 242

SP - 540

EP - 549

JO - Journal of the American Veterinary Medical Association

JF - Journal of the American Veterinary Medical Association

SN - 0003-1488

IS - 4

ER -