Older Age Modifies Oncologic Outcome Following Radiotherapy in Soft-tissue Sarcoma: A Subtype-specific SEER Analysis

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Abstract

BACKGROUND: Given the immune-mediated mechanisms of radiotherapy (RT), we hypothesized that age would affect response to RT in patients with soft-tissue sarcoma (STS) undergoing surgery.

MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results Program (1990-2011), we identified 15,380 patients with non-metastatic STS. Stratified by age (≥65 years) and histological subtype, we assessed predictors of overall (OS) and disease-specific survival (DSS).

RESULTS: Treatment with RT was associated with improved OS and DSS compared to surgery alone (p<0.05). Multivariate analysis also demonstrated that older patients obtained significant improvements in OS following RT, while younger patients did not. Results for DSS were similar, with older patients with leiomyosarcoma, sarcoma not otherwise specified, and myxoid liposarcoma, in particular, showing greater improvements in DSS after RT than younger patients (p<0.05). Interaction testing demonstrated an impact of year of diagnosis on outcomes but not receipt of RT.

CONCLUSION: Among patients with STS undergoing surgery, age appears to impact oncological outcomes after RT.

Original languageEnglish (US)
Pages (from-to)1745-1750
Number of pages6
JournalAnticancer Research
Volume36
Issue number4
StatePublished - Apr 1 2016

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Sarcoma
Radiotherapy
Survival
Myxoid Liposarcoma
SEER Program
Leiomyosarcoma
Multivariate Analysis

Keywords

  • age
  • histology
  • radiotherapy
  • Soft-tissue sarcoma
  • surgery
  • survival

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

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title = "Older Age Modifies Oncologic Outcome Following Radiotherapy in Soft-tissue Sarcoma: A Subtype-specific SEER Analysis",
abstract = "BACKGROUND: Given the immune-mediated mechanisms of radiotherapy (RT), we hypothesized that age would affect response to RT in patients with soft-tissue sarcoma (STS) undergoing surgery.MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results Program (1990-2011), we identified 15,380 patients with non-metastatic STS. Stratified by age (≥65 years) and histological subtype, we assessed predictors of overall (OS) and disease-specific survival (DSS).RESULTS: Treatment with RT was associated with improved OS and DSS compared to surgery alone (p<0.05). Multivariate analysis also demonstrated that older patients obtained significant improvements in OS following RT, while younger patients did not. Results for DSS were similar, with older patients with leiomyosarcoma, sarcoma not otherwise specified, and myxoid liposarcoma, in particular, showing greater improvements in DSS after RT than younger patients (p<0.05). Interaction testing demonstrated an impact of year of diagnosis on outcomes but not receipt of RT.CONCLUSION: Among patients with STS undergoing surgery, age appears to impact oncological outcomes after RT.",
keywords = "age, histology, radiotherapy, Soft-tissue sarcoma, surgery, survival",
author = "Yuen, {Noah K.} and Chin-Shang Li and Monjazeb, {Arta M} and Dariusz Borys and Bold, {Richard J} and Canter, {Robert J}",
year = "2016",
month = "4",
day = "1",
language = "English (US)",
volume = "36",
pages = "1745--1750",
journal = "Anticancer Research",
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TY - JOUR

T1 - Older Age Modifies Oncologic Outcome Following Radiotherapy in Soft-tissue Sarcoma

T2 - A Subtype-specific SEER Analysis

AU - Yuen, Noah K.

AU - Li, Chin-Shang

AU - Monjazeb, Arta M

AU - Borys, Dariusz

AU - Bold, Richard J

AU - Canter, Robert J

PY - 2016/4/1

Y1 - 2016/4/1

N2 - BACKGROUND: Given the immune-mediated mechanisms of radiotherapy (RT), we hypothesized that age would affect response to RT in patients with soft-tissue sarcoma (STS) undergoing surgery.MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results Program (1990-2011), we identified 15,380 patients with non-metastatic STS. Stratified by age (≥65 years) and histological subtype, we assessed predictors of overall (OS) and disease-specific survival (DSS).RESULTS: Treatment with RT was associated with improved OS and DSS compared to surgery alone (p<0.05). Multivariate analysis also demonstrated that older patients obtained significant improvements in OS following RT, while younger patients did not. Results for DSS were similar, with older patients with leiomyosarcoma, sarcoma not otherwise specified, and myxoid liposarcoma, in particular, showing greater improvements in DSS after RT than younger patients (p<0.05). Interaction testing demonstrated an impact of year of diagnosis on outcomes but not receipt of RT.CONCLUSION: Among patients with STS undergoing surgery, age appears to impact oncological outcomes after RT.

AB - BACKGROUND: Given the immune-mediated mechanisms of radiotherapy (RT), we hypothesized that age would affect response to RT in patients with soft-tissue sarcoma (STS) undergoing surgery.MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results Program (1990-2011), we identified 15,380 patients with non-metastatic STS. Stratified by age (≥65 years) and histological subtype, we assessed predictors of overall (OS) and disease-specific survival (DSS).RESULTS: Treatment with RT was associated with improved OS and DSS compared to surgery alone (p<0.05). Multivariate analysis also demonstrated that older patients obtained significant improvements in OS following RT, while younger patients did not. Results for DSS were similar, with older patients with leiomyosarcoma, sarcoma not otherwise specified, and myxoid liposarcoma, in particular, showing greater improvements in DSS after RT than younger patients (p<0.05). Interaction testing demonstrated an impact of year of diagnosis on outcomes but not receipt of RT.CONCLUSION: Among patients with STS undergoing surgery, age appears to impact oncological outcomes after RT.

KW - age

KW - histology

KW - radiotherapy

KW - Soft-tissue sarcoma

KW - surgery

KW - survival

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