Of mice, calves, and men: Comparison of the mouse typhoid model with other Salmonella infections

Renee M Tsolis, R. A. Kingsley, S. M. Townsend, T. A. Ficht, L. G. Adams, Andreas J Baumler

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Numerous Salmonella typhimurium virulence factors have been identified and characterized using experimental infection of mice. While the murine typhoid model has been used successfully for Salmonella typhi vaccine development and to infer virulence mechanisms important during typhoid fever, information derived from infection of mice has been of limited value in elucidating the mechanism by which S. typhimurium causes enteritis in humans. Progress in our understanding of virulence mechanisms contributing to diarrheal disease comes from recent studies of bovine enteritis, a S. typhimurium infection, which manifests as acute gastroenteritis. This review compares virulence genes and mechanisms required during murine typhoid, typhoid fever, and bovine enteritis. Comparison of illnesses caused in different animal hosts identifies virulence mechanisms involved in species specific disease manifestations. The determination of the relative importance of virulence factors for disease manifestations in different host species provides an important link between the in vitro characterization of genes and their role during host pathogen interaction.

Original languageEnglish (US)
Pages (from-to)261-274
Number of pages14
JournalAdvances in Experimental Medicine and Biology
Volume473
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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