Of human loss and erythrocyte survival: Uremia and anemia in chronic kidney disease

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2 Scopus citations

Abstract

Uremia has long been associated with shortened erythrocyte survival .Renal secondary hyperparathyroidism and increased serum parathyroid hormone concentrations have measurable effects on erythrocyte metabolism, osmotic fragility, shape, and deformability that may decrease survival and contribute to the anemia of chronic kidney disease. In addition, excess parathyroid hormone and decreased calcitriol levels can affect a patient's responsiveness to erythropoietin through direct and indirect inhibitory effects on erythropoiesis. Parathyroidectomy or calcitriol treatment for patients with uremia, especially those resistant to the effects of erythropoietin, may result in resolution of anemia .Eitan Bogin, a dedicated and talented biochemist, was one of the first to characterize the role of parathyroid hormone as a uremic toxin with deleterious effects on erythrocytes. The goal of this article is to focus on Eitan Bogin's role in the unfolding story of parathyroid hormone, erythrocytes, and anemia, and the legacy of his scientific contribution to current medical and veterinary treatment of chronic kidney disease.

Original languageEnglish (US)
JournalIsrael Journal of Veterinary Medicine
Volume63
Issue number1
StatePublished - 2008

Keywords

  • Anemia
  • Parathyroid hormone
  • Renal disease
  • Uremia

ASJC Scopus subject areas

  • veterinary(all)
  • Animal Science and Zoology

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