Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig

Hannah E. Wong, Joanna Hedley, Nadene Stapleton, Brian G Murphy, Simon L. Priestnall

Research output: Contribution to journalArticle

Abstract

Odontoameloblastomas (previously incorporated within ameloblastic odontomas) are matrix-producing odontogenic mixed tumors and are closely related in histologic appearance to the 2 other types of matrix-producing odontogenic mixed tumors: odontomas and ameloblastic fibro-odontomas. The presence or absence of intralesional, induced non-neoplastic tissue must be accounted for in the diagnosis. Herein we describe a naturally occurring odontoameloblastoma with extensive chondroid cementum deposition in a guinea pig (Cavia porcellus). Microscopically, the mass featured palisading neoplastic odontogenic epithelium closely apposed to ribbons and rings of a pink dental matrix (dentinoid), alongside extensive sheets and aggregates of chondroid cementum. The final diagnosis was an odontoameloblastoma given the abundance of odontogenic epithelium in association with dentinoid but a paucity of pulp ectomesenchyme. Chondroid cementum is an expected anatomical feature of cavies, and its presence within the odontoameloblastoma was interpreted as a response of the ectomesenchyme of the dental follicle to the described neoplasm. Our case illustrates the inductive capabilities of odontoameloblastomas while highlighting species-specific anatomy that has resulted in a histologic appearance unique to cavies and provides imaging and histologic data to aid diagnosis of these challenging lesions.

Original languageEnglish (US)
Pages (from-to)793-797
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2018

Fingerprint

Odontoma
Dental Cementum
guinea pigs
Odontogenic Tumors
Guinea Pigs
neoplasms
teeth
epithelium
Epithelium
Dental Sac
lesions (animal)
pulp
Anatomy
Tooth
image analysis
Neoplasms

Keywords

  • Chondroid
  • guinea pigs
  • odontoameloblastoma
  • odontogenic mixed tumor

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig. / Wong, Hannah E.; Hedley, Joanna; Stapleton, Nadene; Murphy, Brian G; Priestnall, Simon L.

In: Journal of Veterinary Diagnostic Investigation, Vol. 30, No. 5, 01.09.2018, p. 793-797.

Research output: Contribution to journalArticle

Wong, Hannah E. ; Hedley, Joanna ; Stapleton, Nadene ; Murphy, Brian G ; Priestnall, Simon L. / Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig. In: Journal of Veterinary Diagnostic Investigation. 2018 ; Vol. 30, No. 5. pp. 793-797.
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