Ocular rosacea

Lenio S. Alvarenga, Mark J Mannis

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Rosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea. Ocular manifestations include lid and ocular surface alterations. Chronic inflammation can lead to corneal vascularization, which may compromise vision. Treatment of ocular rosacea is aimed at preventing irritation of the ocular surface (e.g., lubricants, lid hygiene) and controlling inflammation with topical and systemic anti-inflammatory drugs. Systemic tetracyclines are the mainstay of treatment. These drugs act multifactorially by decreasing bacterial flora and the expression of matrix metalloproteinases, altering meibum secretion, inhibiting the production of bacterial lipases, and providing an immunomodulatory effect.

Original languageEnglish (US)
Pages (from-to)41-58
Number of pages18
JournalOcular Surface
Issue number1
StatePublished - Jan 2005


  • Blepharitis
  • Demodex folliculorum
  • Helicobacter pylori
  • Inflammatory disorders
  • Keratitis
  • Metronidazole
  • Ocular inflammation
  • Ocular rosacea
  • Ocular surface
  • Rosacea
  • Tears
  • Tetracyclines

ASJC Scopus subject areas

  • Ophthalmology


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