Abstract
Objective: To determine the characteristics of and prognosis for ocular and periocular hemangiosarcoma in horses. Animal studied: Six horses treated for ocular or periocular hemangiosarcoma. Procedure: A retrospective review of medical records from 2007 to 2015 was performed to identify horses with a histologic diagnosis of ocular or periocular hemangiosarcoma. Signalment (age, sex, breed), duration of clinical signs, prior treatment, tumor size and location, medical and surgical treatment including postoperative chemotherapy, follow-up time, and outcome were obtained from medical records. Histopathology was reviewed by a board-certified pathologist. Results: In six horses diagnosed with ocular or periocular hemangiosarcoma, no breed, age, or sex was overrepresented. Sites included the temporal limbus (3), third eyelid (2), and uvea (1). With the exception of one horse with uveal hemangiosarcoma, 5/6 horses had lightly pigmented periocular haircoat. Histologic features of ocular hemangiosarcoma in 6/6 cases included high cellularity, nuclear pleomorphism, and inflammation with a mitotic index ranging from 0 to 8 mitoses per 10 consecutive 400× fields. Five of six tumors displayed solar elastosis, indicating ultraviolet light-induced damage to sub-epithelial collagen. Treatment included surgical excision in all cases and was not associated with recurrence in 4/6. Three cases that received ancillary treatment with topical mitomycin C had no postoperative recurrence. Two cases with postexcisional recurrence had histologic evidence of incomplete excision. Conclusions: Complete surgical excision may be associated with resolution of periocular and ocular hemangiosarcoma in horses. Etiopathogenesis may include exposure to ultraviolet light.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 432-437 |
| Number of pages | 6 |
| Journal | Veterinary Ophthalmology |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2018 |
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Keywords
- chemotherapy
- hemangiosarcoma
- horse
- ocular
- periocular
- surgery
ASJC Scopus subject areas
- veterinary(all)
Cite this
Ocular and periocular hemangiosarcoma in six horses. / Scherrer, Nicole M.; Utter, Mary; Engiles, Julie.
In: Veterinary Ophthalmology, Vol. 21, No. 4, 01.07.2018, p. 432-437.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Ocular and periocular hemangiosarcoma in six horses
AU - Scherrer, Nicole M.
AU - Utter, Mary
AU - Engiles, Julie
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Objective: To determine the characteristics of and prognosis for ocular and periocular hemangiosarcoma in horses. Animal studied: Six horses treated for ocular or periocular hemangiosarcoma. Procedure: A retrospective review of medical records from 2007 to 2015 was performed to identify horses with a histologic diagnosis of ocular or periocular hemangiosarcoma. Signalment (age, sex, breed), duration of clinical signs, prior treatment, tumor size and location, medical and surgical treatment including postoperative chemotherapy, follow-up time, and outcome were obtained from medical records. Histopathology was reviewed by a board-certified pathologist. Results: In six horses diagnosed with ocular or periocular hemangiosarcoma, no breed, age, or sex was overrepresented. Sites included the temporal limbus (3), third eyelid (2), and uvea (1). With the exception of one horse with uveal hemangiosarcoma, 5/6 horses had lightly pigmented periocular haircoat. Histologic features of ocular hemangiosarcoma in 6/6 cases included high cellularity, nuclear pleomorphism, and inflammation with a mitotic index ranging from 0 to 8 mitoses per 10 consecutive 400× fields. Five of six tumors displayed solar elastosis, indicating ultraviolet light-induced damage to sub-epithelial collagen. Treatment included surgical excision in all cases and was not associated with recurrence in 4/6. Three cases that received ancillary treatment with topical mitomycin C had no postoperative recurrence. Two cases with postexcisional recurrence had histologic evidence of incomplete excision. Conclusions: Complete surgical excision may be associated with resolution of periocular and ocular hemangiosarcoma in horses. Etiopathogenesis may include exposure to ultraviolet light.
AB - Objective: To determine the characteristics of and prognosis for ocular and periocular hemangiosarcoma in horses. Animal studied: Six horses treated for ocular or periocular hemangiosarcoma. Procedure: A retrospective review of medical records from 2007 to 2015 was performed to identify horses with a histologic diagnosis of ocular or periocular hemangiosarcoma. Signalment (age, sex, breed), duration of clinical signs, prior treatment, tumor size and location, medical and surgical treatment including postoperative chemotherapy, follow-up time, and outcome were obtained from medical records. Histopathology was reviewed by a board-certified pathologist. Results: In six horses diagnosed with ocular or periocular hemangiosarcoma, no breed, age, or sex was overrepresented. Sites included the temporal limbus (3), third eyelid (2), and uvea (1). With the exception of one horse with uveal hemangiosarcoma, 5/6 horses had lightly pigmented periocular haircoat. Histologic features of ocular hemangiosarcoma in 6/6 cases included high cellularity, nuclear pleomorphism, and inflammation with a mitotic index ranging from 0 to 8 mitoses per 10 consecutive 400× fields. Five of six tumors displayed solar elastosis, indicating ultraviolet light-induced damage to sub-epithelial collagen. Treatment included surgical excision in all cases and was not associated with recurrence in 4/6. Three cases that received ancillary treatment with topical mitomycin C had no postoperative recurrence. Two cases with postexcisional recurrence had histologic evidence of incomplete excision. Conclusions: Complete surgical excision may be associated with resolution of periocular and ocular hemangiosarcoma in horses. Etiopathogenesis may include exposure to ultraviolet light.
KW - chemotherapy
KW - hemangiosarcoma
KW - horse
KW - ocular
KW - periocular
KW - surgery
UR - http://www.scopus.com/inward/record.url?scp=85049555727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049555727&partnerID=8YFLogxK
U2 - 10.1111/vop.12529
DO - 10.1111/vop.12529
M3 - Review article
C2 - 29111617
AN - SCOPUS:85049555727
VL - 21
SP - 432
EP - 437
JO - Veterinary Ophthalmology
JF - Veterinary Ophthalmology
SN - 1463-5216
IS - 4
ER -