Octreotide infusion or emergency sclerotherapy for variceal haemorrhage

J. J Y Sung, C. W. Lai, F. K L Chan, Joseph Leung, C. Kassianides, S. C S Chung, M. Y. Yung, A. K C Li

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotide (50 μg intravenous bolus plus 50 μg per h intravenous infusion for 48 h). At the end of the study period (48 h), the octreotide group also had sclerotherapy to obliterate the varices. 100 patients were recruited. Demographic features including the aetiology of portal hypertension and the Child- Pugh's grading of the two groups were similar. Bleeding was initially controlled in 90% of patients by emergency sclerotherapy and in 84% by octreotide infusion (95% confidence interval 0-19·5, p=0·55). There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3·5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%). No notable side-effects were associated with octreotide. We conclude that octreotide infusion and emergency sclerotherapy are equally effective in controlling variceal haemorrhage.

Original languageEnglish (US)
Pages (from-to)637-641
Number of pages5
JournalThe Lancet
Volume342
Issue number8872
DOIs
StatePublished - Sep 11 1993
Externally publishedYes

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Sclerotherapy
Octreotide
Emergencies
Hemorrhage
Sodium Tetradecyl Sulfate
Esophageal and Gastric Varices
Varicose Veins
Portal Hypertension
Random Allocation
Hospital Mortality
Intravenous Infusions
Blood Transfusion
Endoscopy
Length of Stay
Demography
Confidence Intervals
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sung, J. J. Y., Lai, C. W., Chan, F. K. L., Leung, J., Kassianides, C., Chung, S. C. S., ... Li, A. K. C. (1993). Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. The Lancet, 342(8872), 637-641. https://doi.org/10.1016/0140-6736(93)91758-E

Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. / Sung, J. J Y; Lai, C. W.; Chan, F. K L; Leung, Joseph; Kassianides, C.; Chung, S. C S; Yung, M. Y.; Li, A. K C.

In: The Lancet, Vol. 342, No. 8872, 11.09.1993, p. 637-641.

Research output: Contribution to journalArticle

Sung, JJY, Lai, CW, Chan, FKL, Leung, J, Kassianides, C, Chung, SCS, Yung, MY & Li, AKC 1993, 'Octreotide infusion or emergency sclerotherapy for variceal haemorrhage', The Lancet, vol. 342, no. 8872, pp. 637-641. https://doi.org/10.1016/0140-6736(93)91758-E
Sung JJY, Lai CW, Chan FKL, Leung J, Kassianides C, Chung SCS et al. Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. The Lancet. 1993 Sep 11;342(8872):637-641. https://doi.org/10.1016/0140-6736(93)91758-E
Sung, J. J Y ; Lai, C. W. ; Chan, F. K L ; Leung, Joseph ; Kassianides, C. ; Chung, S. C S ; Yung, M. Y. ; Li, A. K C. / Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. In: The Lancet. 1993 ; Vol. 342, No. 8872. pp. 637-641.
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