Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis

Gillian M. Nicholas, Tamilyn W. Hong, Tadeusz F. Molinski, Melissa L. Lerch, Mark T. Cancilla, Carlito B Lebrilla

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The structure of oceanapiside, an antifungal α,ω-bis- aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation/ correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 μg/mL (MIC).

Original languageEnglish (US)
Pages (from-to)1678-1681
Number of pages4
JournalJournal of Natural Products
Volume62
Issue number12
DOIs
StatePublished - Dec 1999

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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