Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis

Gillian M. Nicholas, Tamilyn W. Hong, Tadeusz F. Molinski, Melissa L. Lerch, Mark T. Cancilla, Carlito B Lebrilla

Research output: Contribution to journal › Article

59 Citations (Scopus)

Abstract

The structure of oceanapiside, an antifungal α,ω-bis- aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation/ correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 μg/mL (MIC).

Original languageEnglish (US)
Pages (from-to)1678-1681
Number of pages4
JournalJournal of Natural Products
Volume62
Issue number12
DOIs
StatePublished - Dec 1999

Fingerprint

amino alcohols
Amino Alcohols
Candida glabrata
chemical degradation
matrix-assisted laser desorption-ionization mass spectrometry
Porifera
Glycosides
glycosides
spectroscopy
Candida
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Spectrometry
Spectrum Analysis
Nuclear magnetic resonance
Degradation
tandem mass spectrometry
oceanapiside

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Nicholas, G. M., Hong, T. W., Molinski, T. F., Lerch, M. L., Cancilla, M. T., & Lebrilla, C. B. (1999). Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. Journal of Natural Products, 62(12), 1678-1681. https://doi.org/10.1021/np990190v

Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. / Nicholas, Gillian M.; Hong, Tamilyn W.; Molinski, Tadeusz F.; Lerch, Melissa L.; Cancilla, Mark T.; Lebrilla, Carlito B.

In: Journal of Natural Products, Vol. 62, No. 12, 12.1999, p. 1678-1681.

Research output: Contribution to journal › Article

Nicholas, GM, Hong, TW, Molinski, TF, Lerch, ML, Cancilla, MT & Lebrilla, CB 1999, 'Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis', Journal of Natural Products, vol. 62, no. 12, pp. 1678-1681. https://doi.org/10.1021/np990190v
Nicholas GM, Hong TW, Molinski TF, Lerch ML, Cancilla MT, Lebrilla CB. Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. Journal of Natural Products. 1999 Dec;62(12):1678-1681. https://doi.org/10.1021/np990190v
Nicholas, Gillian M. ; Hong, Tamilyn W. ; Molinski, Tadeusz F. ; Lerch, Melissa L. ; Cancilla, Mark T. ; Lebrilla, Carlito B. / Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. In: Journal of Natural Products. 1999 ; Vol. 62, No. 12. pp. 1678-1681.
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