Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis

Gillian M. Nicholas; Tamilyn W. Hong; Tadeusz F. Molinski; Melissa L. Lerch; Mark T. Cancilla; Carlito B Lebrilla

doi:10.1021/np990190v

Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis

Gillian M. Nicholas, Tamilyn W. Hong, Tadeusz F. Molinski, Melissa L. Lerch, Mark T. Cancilla, Carlito B Lebrilla

Biochemistry and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The structure of oceanapiside, an antifungal α,ω-bis- aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation/ correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 μg/mL (MIC).

Original language	English (US)
Pages (from-to)	1678-1681
Number of pages	4
Journal	Journal of Natural Products
Volume	62
Issue number	12
DOIs	https://doi.org/10.1021/np990190v
State	Published - Dec 1999

ASJC Scopus subject areas

Plant Science
Chemistry (miscellaneous)
Drug Discovery
Organic Chemistry
Pharmacology

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10.1021/np990190v

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Oceanapiside, an antifungal bis-α,ω-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. / Nicholas, Gillian M.; Hong, Tamilyn W.; Molinski, Tadeusz F.; Lerch, Melissa L.; Cancilla, Mark T.; Lebrilla, Carlito B.

In: Journal of Natural Products, Vol. 62, No. 12, 12.1999, p. 1678-1681.

Research output: Contribution to journal › Article › peer-review

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