Occupational lead exposure, nephropathy, and renal cancer

Edward L. Baker, Robert A. Goyer, Bruce A. Fowler, Urmila Khettry, David B. Bernard, Stephen Adler, Ralph W deVere White, Richard Babayan, Robert G. Feldman

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A 48‐year‐old lead worker was found to have a cystic renal carcinoma during an evaluation of his occupational lead poisoning. Clinical studies showed elevated blood lead levels, impaired urinary concentrating ability, and reduced creatinine clearance. Histologic and electron microscopic studies showed this cystic tumor to be similar to renal carcinomas observed in animals with prolonged lead exposure. Lead content of the tumor was elevated (2.49 μg/gm) in comparison with adjacent renal tissue and with normal adult levels. In light of previous animal studies, this case adds increased evidence to the concern over the carcinogenic potential of prolonged lead exposure.

Original languageEnglish (US)
Pages (from-to)139-148
Number of pages10
JournalAmerican Journal of Industrial Medicine
Volume1
Issue number2
DOIs
StatePublished - 1980
Externally publishedYes

Keywords

  • chronic renal failure
  • environmental carcinogenesis
  • lead poisoning
  • renal carcinoma

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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  • Cite this

    Baker, E. L., Goyer, R. A., Fowler, B. A., Khettry, U., Bernard, D. B., Adler, S., deVere White, R. W., Babayan, R., & Feldman, R. G. (1980). Occupational lead exposure, nephropathy, and renal cancer. American Journal of Industrial Medicine, 1(2), 139-148. https://doi.org/10.1002/ajim.4700010204