Obstructive Sarcoidosis

Petey Laohaburanakit, Andrew Chan

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Sarcoidosis is a systemic granulomatous disease that frequently involves the lung. Although classically thought of as a restrictive lung disease, airway obstruction has become a recognized feature of the disease in the past years. Sarcoidosis can affect the airway at any level and when the involvement includes small airways, it can resemble more common obstructive airway diseases, such as asthma and chronic bronchitis. Pulmonary function testing and high-resolution computerized tomography of the chest are two important tools to evaluate the presence and extent of airway obstruction in sarcoidosis. Pharmacologic options for the treatment of obstructive sarcoidosis are, in large part, not supported by large, randomized clinical trials. In severe cases of bronchostenosis owing to sarcoidosis granuloma or extrinsic compression from intrathoracic lymphadenopathy, interventional bronchoscopy has successfully been performed, although repeated procedures are usually required. Lung transplantation is an ultimate option in selected patients with late-stage fibrotic disease.

Original languageEnglish (US)
Pages (from-to)115-129
Number of pages15
JournalClinical Reviews in Allergy and Immunology
Volume25
Issue number2
DOIs
StatePublished - Oct 2003

Keywords

  • Airway obstruction
  • High-resolution computerized tomography
  • Interventional bronchoscopy
  • Pulmonary function test
  • Sarcoidosis

ASJC Scopus subject areas

  • Immunology and Allergy

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