Obstetrical and gynecological complications in fragile X carriers: A multicenter study

C. E. Schwartz; J. Dean; P. N. Howard-Peebles; M. Bugge; M. Mikkelsen; N. Tommerup; C. Hull; Randi J Hagerman; J. J A Holden; R. E. Stevenson

doi:10.1002/ajmg.1320510419

Obstetrical and gynecological complications in fragile X carriers: A multicenter study

C. E. Schwartz, J. Dean, P. N. Howard-Peebles, M. Bugge, M. Mikkelsen, N. Tommerup, C. Hull, Randi J Hagerman, J. J A Holden, R. E. Stevenson

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.

Original language	English (US)
Pages (from-to)	400-402
Number of pages	3
Journal	American Journal of Medical Genetics
Volume	51
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.1320510419
State	Published - 1994
Externally published	Yes

Keywords

FMR1 gene
fragile X carriers
irregular menses
oogonia

ASJC Scopus subject areas

Genetics(clinical)

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10.1002/ajmg.1320510419

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Obstetrical and gynecological complications in fragile X carriers : A multicenter study. / Schwartz, C. E.; Dean, J.; Howard-Peebles, P. N.; Bugge, M.; Mikkelsen, M.; Tommerup, N.; Hull, C.; Hagerman, Randi J; Holden, J. J A; Stevenson, R. E.

In: American Journal of Medical Genetics, Vol. 51, No. 4, 1994, p. 400-402.

Research output: Contribution to journal › Article › peer-review

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Obstetrical and gynecological complications in fragile X carriers: A multicenter study

Abstract

Keywords

ASJC Scopus subject areas

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