Obstetrical and gynecological complications in fragile X carriers: A multicenter study

C. E. Schwartz, J. Dean, P. N. Howard-Peebles, M. Bugge, M. Mikkelsen, N. Tommerup, C. Hull, Randi J Hagerman, J. J A Holden, R. E. Stevenson

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.

Original languageEnglish (US)
Pages (from-to)400-402
Number of pages3
JournalAmerican Journal of Medical Genetics
Volume51
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

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Keywords

  • FMR1 gene
  • fragile X carriers
  • irregular menses
  • oogonia

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Schwartz, C. E., Dean, J., Howard-Peebles, P. N., Bugge, M., Mikkelsen, M., Tommerup, N., Hull, C., Hagerman, R. J., Holden, J. J. A., & Stevenson, R. E. (1994). Obstetrical and gynecological complications in fragile X carriers: A multicenter study. American Journal of Medical Genetics, 51(4), 400-402. https://doi.org/10.1002/ajmg.1320510419