Abstract
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
Original language | English (US) |
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Pages (from-to) | 400-402 |
Number of pages | 3 |
Journal | American Journal of Medical Genetics |
Volume | 51 |
Issue number | 4 |
DOIs | |
State | Published - 1994 |
Externally published | Yes |
Keywords
- FMR1 gene
- fragile X carriers
- irregular menses
- oogonia
ASJC Scopus subject areas
- Genetics(clinical)