Abstract
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-402 |
| Number of pages | 3 |
| Journal | American Journal of Medical Genetics |
| Volume | 51 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
Keywords
- FMR1 gene
- fragile X carriers
- irregular menses
- oogonia
ASJC Scopus subject areas
- Genetics(clinical)
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Schwartz, C. E., Dean, J., Howard-Peebles, P. N., Bugge, M., Mikkelsen, M., Tommerup, N., Hull, C., Hagerman, R. J., Holden, J. J. A., & Stevenson, R. E. (1994). Obstetrical and gynecological complications in fragile X carriers: A multicenter study. American Journal of Medical Genetics, 51(4), 400-402. https://doi.org/10.1002/ajmg.1320510419