Abstract
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-402 |
| Number of pages | 3 |
| Journal | American Journal of Medical Genetics |
| Volume | 51 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- FMR1 gene
- fragile X carriers
- irregular menses
- oogonia
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
Obstetrical and gynecological complications in fragile X carriers : A multicenter study. / Schwartz, C. E.; Dean, J.; Howard-Peebles, P. N.; Bugge, M.; Mikkelsen, M.; Tommerup, N.; Hull, C.; Hagerman, Randi J; Holden, J. J A; Stevenson, R. E.
In: American Journal of Medical Genetics, Vol. 51, No. 4, 1994, p. 400-402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obstetrical and gynecological complications in fragile X carriers
T2 - A multicenter study
AU - Schwartz, C. E.
AU - Dean, J.
AU - Howard-Peebles, P. N.
AU - Bugge, M.
AU - Mikkelsen, M.
AU - Tommerup, N.
AU - Hull, C.
AU - Hagerman, Randi J
AU - Holden, J. J A
AU - Stevenson, R. E.
PY - 1994
Y1 - 1994
N2 - We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
AB - We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
KW - FMR1 gene
KW - fragile X carriers
KW - irregular menses
KW - oogonia
UR - http://www.scopus.com/inward/record.url?scp=0028237295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028237295&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320510419
DO - 10.1002/ajmg.1320510419
M3 - Article
C2 - 7943006
AN - SCOPUS:0028237295
VL - 51
SP - 400
EP - 402
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
SN - 1552-4825
IS - 4
ER -