Obstetrical and gynecological complications in fragile X carriers: A multicenter study

C. E. Schwartz; J. Dean; P. N. Howard-Peebles; M. Bugge; M. Mikkelsen; N. Tommerup; C. Hull; Randi J Hagerman; J. J A Holden; R. E. Stevenson

doi:10.1002/ajmg.1320510419

Obstetrical and gynecological complications in fragile X carriers: A multicenter study

C. E. Schwartz, J. Dean, P. N. Howard-Peebles, M. Bugge, M. Mikkelsen, N. Tommerup, C. Hull, Randi J Hagerman, J. J A Holden, R. E. Stevenson

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.

Original language	English (US)
Pages (from-to)	400-402
Number of pages	3
Journal	American Journal of Medical Genetics
Volume	51
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.1320510419
State	Published - 1994
Externally published	Yes

Keywords

FMR1 gene
fragile X carriers
irregular menses
oogonia

ASJC Scopus subject areas

Genetics(clinical)

Access to Document

10.1002/ajmg.1320510419

Fingerprint Dive into the research topics of 'Obstetrical and gynecological complications in fragile X carriers: A multicenter study'. Together they form a unique fingerprint.

Cite this

Obstetrical and gynecological complications in fragile X carriers : A multicenter study. / Schwartz, C. E.; Dean, J.; Howard-Peebles, P. N.; Bugge, M.; Mikkelsen, M.; Tommerup, N.; Hull, C.; Hagerman, Randi J; Holden, J. J A; Stevenson, R. E.

In: American Journal of Medical Genetics, Vol. 51, No. 4, 1994, p. 400-402.

Research output: Contribution to journal › Article › peer-review

@article{a4b755302593405e954507c13f45738d,

title = "Obstetrical and gynecological complications in fragile X carriers: A multicenter study",

abstract = "We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.",

keywords = "FMR1 gene, fragile X carriers, irregular menses, oogonia",

author = "Schwartz, {C. E.} and J. Dean and Howard-Peebles, {P. N.} and M. Bugge and M. Mikkelsen and N. Tommerup and C. Hull and Hagerman, {Randi J} and Holden, {J. J A} and Stevenson, {R. E.}",

year = "1994",

doi = "10.1002/ajmg.1320510419",

language = "English (US)",

volume = "51",

pages = "400--402",

journal = "American Journal of Medical Genetics",

issn = "1552-4825",

publisher = "Wiley-Liss Inc.",

number = "4",

}

TY - JOUR

T1 - Obstetrical and gynecological complications in fragile X carriers

T2 - A multicenter study

AU - Schwartz, C. E.

AU - Dean, J.

AU - Howard-Peebles, P. N.

AU - Bugge, M.

AU - Mikkelsen, M.

AU - Tommerup, N.

AU - Hull, C.

AU - Hagerman, Randi J

AU - Holden, J. J A

AU - Stevenson, R. E.

PY - 1994

Y1 - 1994

N2 - We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.

AB - We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.

KW - FMR1 gene

KW - fragile X carriers

KW - irregular menses

KW - oogonia

UR - http://www.scopus.com/inward/record.url?scp=0028237295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028237295&partnerID=8YFLogxK

U2 - 10.1002/ajmg.1320510419

DO - 10.1002/ajmg.1320510419

M3 - Article

C2 - 7943006

AN - SCOPUS:0028237295

VL - 51

SP - 400

EP - 402

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

SN - 1552-4825

IS - 4

ER -

Obstetrical and gynecological complications in fragile X carriers: A multicenter study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this