Obstetric complications and risk for conversion to psychosis among individuals at high clinical risk

Vijay A. Mittal, Rachael Willhite, Melita Daley, Carrie E. Bearden, Tara A Niendam, Lauren M. Ellman, Tyrone D. Cannon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aim: Examining risk factors among high-risk populations stands to inform treatment and to elucidate our understanding of the pathophysiology of schizophrenia. Despite substantial evidence implicating the incidence of obstetric complications (OCs) as a risk factor for schizophrenia, little is known about the relationship between OCs and risk for conversion among high-risk individuals. Methods: We prospectively followed individuals at high risk for developing psychotic disorders for a two-year period to determine if a history of OCs is associated with conversion. Results: Individuals who converted to psychosis had significantly more OCs when compared to non-converting participants; a history of OCs was associated with increased odds of conversion (odds ratio=4.90, confidence interval: 1.04/22.20). OCs were positively associated with prodromal symptomatology. Conclusions: To date, this report represents the first empirical evidence suggesting that OCs confer increased risk of conversion to psychosis. It is possible that OCs interact with brain maturational processes in the pathophysiology of schizophrenia and can serve as a risk marker.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalEarly Intervention in Psychiatry
Volume3
Issue number3
DOIs
StatePublished - 2009

Fingerprint

Psychotic Disorders
Obstetrics
Schizophrenia
Odds Ratio
Confidence Intervals
Incidence
Brain
Population

Keywords

  • Conversion
  • Obstetric complications
  • Prodromal
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Phychiatric Mental Health
  • Biological Psychiatry

Cite this

Obstetric complications and risk for conversion to psychosis among individuals at high clinical risk. / Mittal, Vijay A.; Willhite, Rachael; Daley, Melita; Bearden, Carrie E.; Niendam, Tara A; Ellman, Lauren M.; Cannon, Tyrone D.

In: Early Intervention in Psychiatry, Vol. 3, No. 3, 2009, p. 226-230.

Research output: Contribution to journalArticle

Mittal, Vijay A. ; Willhite, Rachael ; Daley, Melita ; Bearden, Carrie E. ; Niendam, Tara A ; Ellman, Lauren M. ; Cannon, Tyrone D. / Obstetric complications and risk for conversion to psychosis among individuals at high clinical risk. In: Early Intervention in Psychiatry. 2009 ; Vol. 3, No. 3. pp. 226-230.
@article{4407f648a07c4382ab968e4c5d360dfd,
title = "Obstetric complications and risk for conversion to psychosis among individuals at high clinical risk",
abstract = "Aim: Examining risk factors among high-risk populations stands to inform treatment and to elucidate our understanding of the pathophysiology of schizophrenia. Despite substantial evidence implicating the incidence of obstetric complications (OCs) as a risk factor for schizophrenia, little is known about the relationship between OCs and risk for conversion among high-risk individuals. Methods: We prospectively followed individuals at high risk for developing psychotic disorders for a two-year period to determine if a history of OCs is associated with conversion. Results: Individuals who converted to psychosis had significantly more OCs when compared to non-converting participants; a history of OCs was associated with increased odds of conversion (odds ratio=4.90, confidence interval: 1.04/22.20). OCs were positively associated with prodromal symptomatology. Conclusions: To date, this report represents the first empirical evidence suggesting that OCs confer increased risk of conversion to psychosis. It is possible that OCs interact with brain maturational processes in the pathophysiology of schizophrenia and can serve as a risk marker.",
keywords = "Conversion, Obstetric complications, Prodromal, Psychosis, Schizophrenia",
author = "Mittal, {Vijay A.} and Rachael Willhite and Melita Daley and Bearden, {Carrie E.} and Niendam, {Tara A} and Ellman, {Lauren M.} and Cannon, {Tyrone D.}",
year = "2009",
doi = "10.1111/j.1751-7893.2009.00137.x",
language = "English (US)",
volume = "3",
pages = "226--230",
journal = "Early Intervention in Psychiatry",
issn = "1751-7885",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Obstetric complications and risk for conversion to psychosis among individuals at high clinical risk

AU - Mittal, Vijay A.

AU - Willhite, Rachael

AU - Daley, Melita

AU - Bearden, Carrie E.

AU - Niendam, Tara A

AU - Ellman, Lauren M.

AU - Cannon, Tyrone D.

PY - 2009

Y1 - 2009

N2 - Aim: Examining risk factors among high-risk populations stands to inform treatment and to elucidate our understanding of the pathophysiology of schizophrenia. Despite substantial evidence implicating the incidence of obstetric complications (OCs) as a risk factor for schizophrenia, little is known about the relationship between OCs and risk for conversion among high-risk individuals. Methods: We prospectively followed individuals at high risk for developing psychotic disorders for a two-year period to determine if a history of OCs is associated with conversion. Results: Individuals who converted to psychosis had significantly more OCs when compared to non-converting participants; a history of OCs was associated with increased odds of conversion (odds ratio=4.90, confidence interval: 1.04/22.20). OCs were positively associated with prodromal symptomatology. Conclusions: To date, this report represents the first empirical evidence suggesting that OCs confer increased risk of conversion to psychosis. It is possible that OCs interact with brain maturational processes in the pathophysiology of schizophrenia and can serve as a risk marker.

AB - Aim: Examining risk factors among high-risk populations stands to inform treatment and to elucidate our understanding of the pathophysiology of schizophrenia. Despite substantial evidence implicating the incidence of obstetric complications (OCs) as a risk factor for schizophrenia, little is known about the relationship between OCs and risk for conversion among high-risk individuals. Methods: We prospectively followed individuals at high risk for developing psychotic disorders for a two-year period to determine if a history of OCs is associated with conversion. Results: Individuals who converted to psychosis had significantly more OCs when compared to non-converting participants; a history of OCs was associated with increased odds of conversion (odds ratio=4.90, confidence interval: 1.04/22.20). OCs were positively associated with prodromal symptomatology. Conclusions: To date, this report represents the first empirical evidence suggesting that OCs confer increased risk of conversion to psychosis. It is possible that OCs interact with brain maturational processes in the pathophysiology of schizophrenia and can serve as a risk marker.

KW - Conversion

KW - Obstetric complications

KW - Prodromal

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=69949089717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949089717&partnerID=8YFLogxK

U2 - 10.1111/j.1751-7893.2009.00137.x

DO - 10.1111/j.1751-7893.2009.00137.x

M3 - Article

VL - 3

SP - 226

EP - 230

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

SN - 1751-7885

IS - 3

ER -