Obsessive compulsive symptoms in the psychosis prodrome: Correlates of clinical and functional outcome

Tara A Niendam, Jodi Berzak, Tyrone D. Cannon, Carrie E. Bearden

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Objectives: Obsessive-Compulsive Disorder (OCD) is a common co-morbid condition in schizophrenia, associated with poor prognosis. However, the prevalence of obsessive compulsive symptomatology (OCS) and its relationship to outcome has not been evaluated in adolescents at ultra high-risk for psychosis (UHR). Methods: Sixty-four UHR and 26 non-prodromal comparison (NPC) youth were ascertained using the Structured Interview for Prodromal Syndromes (SIPS). Participants completed diagnostic interviews and the Padua Inventory (Sanavio, E., 1988. Obsessions and compulsions: the Padua Inventory. Behav. Res. Ther. 26, 169-177.), a self-report measure of OCS. Results: UHR youth reported significantly higher rates of OCS on the Padua Inventory compared to NPC youth. Clinical diagnosis of OCD (20% of sample) was associated with lower risk of conversion to psychosis over the follow-up period, but was unrelated to clinical severity or psychosocial functioning. However, dimensional ratings of OCS were significantly associated with positive symptom severity, self-reported depression, and a trend toward increased suicidal ideation within the UHR sample. Conclusions: OCS rates in UHR youth are well above estimated prevalence rates in normal populations, and commensurate with rates of comorbidity observed in schizophrenia. Although clinical diagnosis of OCD was not associated with later conversion to psychosis, OCS severity in UHR youth was associated with more acute symptomatic presentation, including more severe depression and suicidality.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalSchizophrenia Research
Issue number1-3
StatePublished - Mar 2009


  • Anxiety
  • Obsessive-compulsive
  • Prodrome
  • Psychosis
  • Psychosocial functioning
  • Ultra-high-risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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