Observing the deoxy myoglobin and hemogobin signals from rat myocardium in situ

Tuan Khanh Tran, Ulrike Kreutzer, Thomas Jue

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1H NMR proximal histidyl N(δ)H signals of deoxy hemoglobin (Hb) and myoglobin (Mb) are distinguishable in the rat myocardium in situ. In the normoxic resting state, the blood and tissue pO2 is sufficient to saturate both Mb and Hb. No deoxy Mb or Hb signals are detected. Under 12% inspired O2, the erythrocyte Hb is partially desaturated and yields the α and β proximal histidyl N(δ)H signals of deoxy Hb. The detection of the Hb signals clarifies the debate about the NMR visibility of erythrocyte Hb in vivo and augments the strategy to observe tissue pO2. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalFEBS Letters
Volume434
Issue number3
DOIs
StatePublished - Sep 4 1998

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Myoglobin
Rats
Myocardium
Hemoglobins
Erythrocytes
Nuclear magnetic resonance
Tissue
Visibility
Blood

Keywords

  • Hemoglobin
  • Myocardium
  • Myoglobin
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Observing the deoxy myoglobin and hemogobin signals from rat myocardium in situ. / Tran, Tuan Khanh; Kreutzer, Ulrike; Jue, Thomas.

In: FEBS Letters, Vol. 434, No. 3, 04.09.1998, p. 309-312.

Research output: Contribution to journalArticle

Tran, Tuan Khanh ; Kreutzer, Ulrike ; Jue, Thomas. / Observing the deoxy myoglobin and hemogobin signals from rat myocardium in situ. In: FEBS Letters. 1998 ; Vol. 434, No. 3. pp. 309-312.
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